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Abstract
To characterize Parkinson’s disease, abnormal phase-amplitude coupling is assessed in the cortico-basal circuit using invasive recordings. It is unknown whether the same phenomenon might be found in regions other than the cortico-basal ganglia circuit. We hypothesized that using magnetoencephalography to assess phase-amplitude coupling in the whole brain can characterize Parkinson’s disease. We recorded resting-state magnetoencephalographic signals in patients with Parkinson’s disease and in healthy age- and sex-matched participants. We compared whole-brain signals from the two groups, evaluating the power spectra of 3 frequency bands (alpha, 8–12 Hz; beta, 13–25 Hz; gamma, 50–100 Hz) and the coupling between gamma amplitude and alpha or beta phases. Patients with Parkinson’s disease showed significant beta–gamma phase-amplitude coupling that was widely distributed in the sensorimotor, occipital, and temporal cortices; healthy participants showed such coupling only in parts of the somatosensory and temporal cortices. Moreover, beta- and gamma-band power differed significantly between participants in the two groups (P < 0.05). Finally, beta–gamma phase-amplitude coupling in the sensorimotor cortices correlated significantly with motor symptoms of Parkinson’s disease (P < 0.05); beta- and gamma-band power did not. We thus demonstrated that beta–gamma phase-amplitude coupling in the resting state characterizes Parkinson’s disease.
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1 Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971)
2 Osaka University Graduate School of Medicine, Department of Neurosurgery, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971); Osaka University, Institute for Advanced Co-Creation Studies, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971); ATR Computational Neuroscience Laboratories, Department of Neuroinformatics, Kyoto, Japan (GRID:grid.418163.9) (ISNI:0000 0001 2291 1583)
3 Osaka University Graduate School of Medicine, Department of Neurology, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971)
4 Osaka University Graduate School of Medicine, Department of Neurology, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971); University of Toyama, Department of Rehabilitation, Faculty of Medicine, Academic Assembly, Toyama, Japan (GRID:grid.267346.2) (ISNI:0000 0001 2171 836X)
5 National Center of Neurology and Psychiatry, Department of Pathology of Mental Diseases, National Institute of Mental Health, Kodaira, Japan (GRID:grid.419280.6) (ISNI:0000 0004 1763 8916); Osaka University Graduate School of Medicine, Department of Psychiatry, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971); Osaka University, Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971)
6 Osaka University Graduate School of Medicine, Department of Psychiatry, Suita, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971)