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Copyright © 2022 Rubén Queiro et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

The human leukocyte antigen-C06 (HLA-C06, formerly HLA-Cw6) is the main genetic biomarker in psoriatic disease. It has been related to several phenotypic traits in psoriatic disease, but its role in relation to cardiometabolic comorbidities is unknown at present. Here, we analyze the potential connections between this biomarker and the cardiometabolic profile of these patients. We carried out a cross-sectional observational study including 400 patients recruited at a single university hospital. Clinical and classical cardiometabolic factors were compared between HLA-C06-positive and HLA-C06-negative individuals (OR with 95% CI). Multivariate regression analyses were carried out to check for disease traits associated with different cardiometabolic risk factors. The study population included 215 men (53.8%) and 185 women (46.2%), mean age of 46±15years, and an average disease evolution of 17±12.6years. Ninety-three (23.3%) patients met CASPAR criteria for psoriatic arthritis. HLA-C06 carriers (n: 160, 40%) showed an earlier age at disease onset, psoriasis family history, and more severe skin disease (type I disease). After correcting for age, sex, and disease duration, they also showed less hypertension (13.8% vs. 24.2%, OR 0.7 (95% CI: 0.42-0.78), p=0.025), lower waist circumference (94.4±13.7 vs. 98.3±13.8cm), and lower BMI (27±4.4 vs. 28.1±4.8, p<0.05). We confirmed the well-known association between HLA-C06 and type I psoriatic disease. As a novel finding, patients carrying HLA-C06 showed a better cardiometabolic profile. In any case, these findings need further confirmation.

Details

Title
Potential Differences in the Cardiometabolic Risk Profile of Patients with Psoriatic Disease according to Their HLA-C∗06 Status
Author
Queiro, Rubén 1   VIAFID ORCID Logo  ; Coto-Segura, Pablo 2 ; Braña, Ignacio 3 ; Pino, Marina 3 ; Burger, Stefanie 3 

 Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain; ISPA Translational Immunology Division, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain; Oviedo University School of Medicine, Spain 
 Dermatology Division, Hospital Vital Alvarez Buylla, Mieres, Asturias, Spain 
 Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain 
Editor
Luisa Brussino
Publication year
2022
Publication date
2022
Publisher
John Wiley & Sons, Inc.
ISSN
23146133
e-ISSN
23146141
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2625914061
Copyright
Copyright © 2022 Rubén Queiro et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/