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Abstract
This study investigated the diagnostic accuracy and affecting factors of ultrasound (US)-guided core-needle biopsy (CNB) in patients with treated head and neck squamous cell carcinoma (HNSCC). We retrospectively reviewed patients with treated HNSCC who received US-guided CNB from January 2011 to December 2018 with corresponding imaging. Pathological necrosis and fibrosis of targeted lymph nodes (LNs) were evaluated. We analyzed the correlation between CNB accuracy and clinical and pathological characteristics. In total, 260 patients were included. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of CNB for nodal recurrence were 84.47%, 100%, 100%, 54.67%, and 86.92%, respectively. CNB of fibrotic LNs had significantly worse sensitivity, NPV, and accuracy than that of non-fibrotic LNs. Similarly, CNB of necrotic LNs had significantly worse sensitivity, NPV, and accuracy than non-necrotic LNs. Multivariate regression revealed that fibrotic LN was the only independent factor for a true positive rate, whereas both necrotic LN and fibrotic LN were independent factors for a false negative rate. The diagnostic accuracy of CNB in treated HNSCC patients is affected by LN necrosis and fibrosis. Therefore, CNB results, particularly for necrotic or fibrotic LNs, should be interpreted carefully.
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Details
1 National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Otolaryngology, Taipei, Taiwan, ROC (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); National Taiwan University Hospital Hsin-Chu Biomedical Park Branch, Department of Otolaryngology, Hsinchu, Taiwan, ROC (GRID:grid.412094.a) (ISNI:0000 0004 0572 7815)
2 National Taiwan University Hospital and National Taiwan University College of Medicine, Department of Otolaryngology, Taipei, Taiwan, ROC (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241)
3 National Taiwan University Cancer Center and National Taiwan University College of Medicine, Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan, ROC (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241); National Taiwan University College of Medicine, Graduate Institute of Pathology, Taipei, Taiwan, ROC (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241)