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© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

To assess the relationship between memory performance defined by the Stages of Objective Memory Impairment (SOMI) system and the Alzheimer's disease (AD) ATN (amyloid beta [A], pathologic tau [T], and neurodegeneration [N]) biomarker system.

Methods

We used data from the Harvard Aging Brain Study cohort to estimate the level of ATN biomarkers: amyloid beta (C‐Pittsburgh compound B‐positron emission tomography [PET]), tau (F‐18–flortaucipir [FTP] PET), and neurodegeneration (magnetic resonance imaging volumetrics). We assessed the cross‐sectional relationship of SOMI classification with global amyloid levels, entorhinal and inferior temporal tau deposition, and hippocampal atrophy.

Results

Participants with both memory storage and retrieval deficits (SOMI‐3, ‐4) had smaller hippocampal volumes and higher entorhinal and inferior temporal tau burden than participants with no memory impairment (SOMI‐0) or mild retrieval difficulty (SOMI‐1). Amyloid burden did not differ among SOMI stages.

Discussion

This pilot supports the close relationship between tau pathology and memory impairment across the AD continuum.  SOMI may be useful to determine eligibility for randomized controlled trials prior to the assessment of biomarker status.

Details

Title
Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system
Author
Grober, Ellen 1 ; Papp, Kathryn V 2 ; Rentz, Dorene M 2 ; Sperling, Reisa A 2 ; Johnson, Keith A 2 ; Amariglio, Rebecca E 2 ; Schultz, Aaron 3 ; Lipton, Richard B 1 ; Ezzati, Ali 1 

 Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA 
 Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA 
 Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 
Section
COGNITIVE & BEHAVIORAL ASSESSMENT
Publication year
2021
Publication date
2021
Publisher
John Wiley & Sons, Inc.
e-ISSN
23528729
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2628240321
Copyright
© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.