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© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction

This study sought to determine whether adding cognition to a model with Alzheimer's disease biomarkers based on the amyloid, tau, and neurodegeneration/neuronal injury—AT(N)—biomarker framework predicts rates of cognitive and functional decline in older adults without dementia.

Methods

The study included 465 participants who completed amyloid positron emission tomography, cerebrospinal fluid phosphorylated tau, structural magnetic resonance imaging, and serial neuropsychological testing. Using the AT(N) framework and a newly validated cognitive metric as the independent variables, we used linear mixed effects models to examine a 4‐year rate of change in cognitive and functional measures.

Results

The inclusion of baseline cognitive status improved model fit in predicting rate of decline in outcomes above and beyond biomarker variables. Specifically, those with worse cognitive functioning at baseline had faster rates of memory and functional decline over a 4‐year period, even when accounting for AT(N).

Discussion

Including a newly validated measure of baseline cognition may improve clinical prognosis in non‐demented older adults beyond the use of AT(N) biomarkers alone.

Details

Title
Adding cognition to AT(N) models improves prediction of cognitive and functional decline
Author
O'Shea, Deirdre M 1   VIAFID ORCID Logo  ; Thomas, Kelsey R 2 ; Breton Asken 3 ; Athene K.W. Lee 1 ; Davis, Jennifer D 1 ; Malloy, Paul F 1 ; Salloway, Stephen P 1 ; Correia, Stephen 1 

 Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA 
 Research Service, VA San Diego Healthcare System, University of California San Diego, San Diego, California, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA 
 Department of Neurology, University of California San Francisco, San Francisco, California, USA 
Section
COGNITIVE & BEHAVIORAL ASSESSMENT
Publication year
2021
Publication date
2021
Publisher
John Wiley & Sons, Inc.
e-ISSN
23528729
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2628240431
Copyright
© 2021. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.