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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Simple Summary

Although emerging studies support the relationship between S100 calcium binding protein A7 (S100A7) and various cancers, no pancancer analysis of S100A7 is available thus far. Therefore, we investigated the potential oncogenic roles of S100A7 across 33 tumors based on datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Higher levels of S100A7 were observed in most types of tumors, and importantly, S100A7 seemed to be a prognosis marker of the tumor subjects. In addition, S100A7 levels were associated with the infiltration level of CD8+ T cells and cancer-associated fibroblasts in different tumors. Moreover, the dysregulation of glycosaminoglycan and lysosome was associated with S100A7 functional mechanisms. The current pancancer study offers a relatively integrative understanding of the carcinogenic involvement of S100A7 in numerous types of cancers.

Abstract

Background: Although emerging studies support the relationship between S100 calcium binding protein A7 (S100A7) and various cancers, no pancancer analysis of S100A7 is available thus far. Methods: We investigated the potential oncogenic roles of S100A7 across 33 tumors based on datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Moreover, a survival prognosis analysis was performed with the gene expression profiling interactive analysis (GEPIA) web server and Kaplan–Meier plotter, followed by the genetic alteration analysis of S100A7 and enrichment analysis of S100A7-related genes. Results: S100A7 was highly expressed in most types of cancers, and remarkable associations were found between S100A7 expression and the prognosis of cancer patients. S100A7 expression was associated with the expression of DNA methyltransferase and mismatch repair genes in head and neck squamous cell carcinoma, the infiltration of CD8+ T cells and cancer-associated fibroblasts in different tumors. Moreover, glycosaminoglycan degradation and lysosome-associated functions were involved in the functional mechanisms of S100A7. Conclusions: The current pancancer study shows a relatively integrative understanding of the carcinogenic involvement of S100A7 in numerous types of cancers.

Details

Title
A Pancancer Analysis of the Oncogenic Role of S100 Calcium Binding Protein A7 (S100A7) in Human Tumors
Author
Ge Peng 1   VIAFID ORCID Logo  ; Tsukamoto, Saya 1 ; Okumura, Ko 2 ; Ogawa, Hideoki 2 ; Ikeda, Shigaku 1 ; Niyonsaba, François 3   VIAFID ORCID Logo 

 Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; [email protected] (G.P.); [email protected] (S.T.); [email protected] (S.I.); Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; [email protected] (K.O.); [email protected] (H.O.) 
 Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; [email protected] (K.O.); [email protected] (H.O.) 
 Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; [email protected] (K.O.); [email protected] (H.O.); Faculty of International Liberal Arts, Juntendo University, Tokyo 113-8421, Japan 
First page
284
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20797737
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2632247141
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.