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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios, including liver resection and transplantation. Various studies and countless surgical events have led to the observation of a strong correlation between HIRI induced by liver transplantation and early allograft-dysfunction development. The detrimental impact of HIRI has driven the pursuit of new ways to alleviate its adverse effects. At the core of HIRI lies mitochondrial dysfunction. Various studies, from both animal models and in clinical settings, have clearly shown that mitochondrial function is severely hampered by HIRI and that its preservation or restoration is a key indicator of successful organ recovery. Several strategies have been thus implemented throughout the years, targeting mitochondrial function. This work briefly discusses some the most utilized approaches, ranging from surgical practices to pharmacological interventions and highlights how novel strategies can be investigated and implemented by intricately discussing the way mitochondrial function is affected by HIRI.

Details

Title
Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria
Author
Teodoro, João S 1   VIAFID ORCID Logo  ; Da Silva, Rui T 2   VIAFID ORCID Logo  ; Machado, Ivo F 3   VIAFID ORCID Logo  ; Panisello-Roselló, Arnau 4 ; Roselló-Catafau, Joan 4 ; Rolo, Anabela P 5 ; Palmeira, Carlos M 5   VIAFID ORCID Logo 

 MitoLab, Department of Life Sciences, University of Coimbra, 3000 Coimbra, Portugal; [email protected] (J.S.T.); [email protected] (A.P.R.); MitoLab, Mitochondria, Metabolism and Disease Group, Center for Neurosciences and Cell Biology, Faculdade de Medicina, University of Coimbra, 3000 Coimbra, Portugal; [email protected] (R.T.D.S.); [email protected] (I.F.M.); IIIUC–Institute of Interdisciplinary Research, University of Coimbra, Pólo II da Universidade de Coimbra, 3000 Coimbra, Portugal 
 MitoLab, Mitochondria, Metabolism and Disease Group, Center for Neurosciences and Cell Biology, Faculdade de Medicina, University of Coimbra, 3000 Coimbra, Portugal; [email protected] (R.T.D.S.); [email protected] (I.F.M.); Experimental Pathology Department, Institute of Biomedical Research of Barcelona (IIBB), CSIC-IDIBAPS, 08036 Barcelona, Spain; [email protected] (A.P.-R.); [email protected] (J.R.-C.) 
 MitoLab, Mitochondria, Metabolism and Disease Group, Center for Neurosciences and Cell Biology, Faculdade de Medicina, University of Coimbra, 3000 Coimbra, Portugal; [email protected] (R.T.D.S.); [email protected] (I.F.M.); IIIUC–Institute of Interdisciplinary Research, University of Coimbra, Pólo II da Universidade de Coimbra, 3000 Coimbra, Portugal 
 Experimental Pathology Department, Institute of Biomedical Research of Barcelona (IIBB), CSIC-IDIBAPS, 08036 Barcelona, Spain; [email protected] (A.P.-R.); [email protected] (J.R.-C.) 
 MitoLab, Department of Life Sciences, University of Coimbra, 3000 Coimbra, Portugal; [email protected] (J.S.T.); [email protected] (A.P.R.); MitoLab, Mitochondria, Metabolism and Disease Group, Center for Neurosciences and Cell Biology, Faculdade de Medicina, University of Coimbra, 3000 Coimbra, Portugal; [email protected] (R.T.D.S.); [email protected] (I.F.M.) 
First page
688
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20734409
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2632528885
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.