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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ or in vitro, with toxic effects. It has been shown that some molecules affect the immune system, e.g., Masticadienonic acid (MDA) and 3α-hydroxy masticadienoic acid (3α-OH MDA) triterpenes naturally occurring in several medicinal plants, since they activate the nitric oxide synthase in macrophages and induce T lymphocyte proliferation. The DCs maturation induced by MDA or 3a-OH MDA was determined by incubating these cells with MDA or 3α-OH MDA, and their phenotype was afterwards analyzed. The results showed that only 3α-OH MDA was able to induce DCs maturation. When mice with melanoma were inoculated with DCs/3α-OH MDA, a decreased tumor growth rate was observed along with an extended cell death area within tumors compared to mice treated with DCs incubated with MDA. In conclusion, it is proposed that 3α-OH MDA may be an immunostimulant molecule. Conversely, it is proposed that MDA may be a molecule with anti-inflammatory properties.

Details

Title
Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells
Author
Piñón-Zárate, Gabriela 1   VIAFID ORCID Logo  ; Reyes-Riquelme, Fernanda 1 ; Sánchez-Monroy, Ma Beatriz 2 ; Velasco-Torrez, Mónica 1 ; Martínez-Vázquez, Mariano 3   VIAFID ORCID Logo  ; Cárdenas-Monroy, Christian Adrian 1   VIAFID ORCID Logo  ; Hernandez-Téllez, Beatriz 1 ; Jarquín-Yáñez, Katia 1   VIAFID ORCID Logo  ; Herrera-Enríquez, Miguel Ángel 1 ; Castell-Rodríguez, Andrés Eliú 1   VIAFID ORCID Logo 

 Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico; [email protected] (G.P.-Z.); [email protected] (F.R.-R.); [email protected] (M.V.-T.); [email protected] (Ch.A.C.-M.); [email protected] (B.H.-T.); [email protected] (K.J.-Y.); [email protected] (M.Á.H.-E.) 
 Departamento de Ecología y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico; [email protected] 
 Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico; [email protected] 
First page
1451
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
14203049
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2633032634
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.