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Copyright: © 2021 Kuswari M et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Sea grapes or  Caulerpa racemosa have a lot of phytochemical content, especially unsaturated fatty acids that are beneficial for health. This study aims to evaluate the effects of sea grapes extract on blood glucose levels, total cholesterol-, and Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α in male Wistar rats, which were given per-oral (p.o.) cholesterol- and carbohydrates fat-enriched diets (CFED). Methods: Forty male Wistar albino rats weighing between 200 – 250 g were used for this study. Animals were randomly distributed into four groups of ten animals each. Group A served as control (received standard dry pellet diet). Rats in group B were fed on CFED for 4 weeks.  Groups C and D were fed on CFED and were administered 150 and 450 mg/kg of  sea grapes extract (p.o.), respectively. Results: Group C rats indicated a blood glucose reduction and an increase in PGC-1α serum, in comparison to group D (p<0.05). There were no significant differences between group C and D in blood cholesterol reduction (high dose of the extract did not have significant effects) (p=0.222), and both groups had the same effect in lowering total cholesterol in rats.  Conclusion: Sea grapes extract is proven to improve blood glucose, total cholesterol, and PGC-1α levels in rats fed with CFED.

Details

Title
Sea grapes extract improves blood glucose, total cholesterol, and PGC-1α in rats fed on cholesterol- and fat-enriched diet
Author
Mury, Kuswari; Fahrul, Nurkolis; Mayulu Nelly; Maulana, Ibrahim Faisal; Astuti, Taslim Nurpudji; Wewengkang Defny Silvia; Nindy, Sabrina; Arifin Ghafur Rasyid; Mantik Keren Esther Kristina; Bahar Muhammad Rahimi; Najda, Rifqiyati; Rompies Ronald; Augusta Piko Satria; Permatasari Happy Kurnia
University/institution
U.S. National Institutes of Health/National Library of Medicine
Publication year
2021
Publication date
2021
Publisher
Faculty of 1000 Ltd.
e-ISSN
20461402
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2634423973
Copyright
Copyright: © 2021 Kuswari M et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.