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Abstract
The TAR DNA Binding Protein (TARDBP) gene has become relevant after the discovery of its several pathogenic mutations. The lack of evolutionary history is in contrast to the amount of studies found in the literature. This study investigated the evolutionary dynamics associated with the retrotransposition of the TARDBP gene in primates. We identified novel retropseudogenes that likely originated in the ancestors of anthropoids, catarrhines, and lemuriformes, i.e. the strepsirrhine clade that inhabit Madagascar. We also found species-specific retropseudogenes in the Philippine tarsier, Bolivian squirrel monkey, capuchin monkey and vervet. The identification of a retropseudocopy of the TARDBP gene overlapping a lncRNA that is potentially expressed opens a new avenue to investigate TARDBP gene regulation, especially in the context of TARDBP associated pathologies.
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1 Universidad Austral de Chile, Integrative Biology Group, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Universidad Austral de Chile, Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD), Valdivia, Chile (GRID:grid.511637.7)
2 Universidad Austral de Chile, Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X)
3 Universidad Austral de Chile, Integrative Biology Group, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Universidad Austral de Chile, Instituto de Ciencias Marinas y Limnológicas, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Universidad Austral de Chile, Centro Fondap de Investigación de Altas Latitudes (IDEAL), Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X)
4 Universidad Austral de Chile, Integrative Biology Group, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Universidad Austral de Chile, Applied Biochemistry Laboratory, Facultad de Ciencias Veterinarias, Instituto de Farmacología y Morfofisiología, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X)
5 Universidad Austral de Chile, Integrative Biology Group, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Universidad Austral de Chile, Department of Physiology, School of Medicine, Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X); Universidad Austral de Chile, Center for Interdisciplinary Studies of the Nervous System (CISNe), Valdivia, Chile (GRID:grid.7119.e) (ISNI:0000 0004 0487 459X)