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Abstract
Existing methods for biopsy of intraparenchymal brain lesions, including stereotactic biopsy and open block biopsy, have advantages and disadvantages. We propose a novel biopsy method, called “boring biopsy,” which aims to overcome the drawbacks of each conventional method. This method is less invasive and allows obtaining continuous specimens of sufficient volume. We aimed to assess the feasibility and efficacy of using boring biopsy for intraparenchymal brain lesions. We included 26 consecutive patients who underwent boring biopsy for intraparenchymal lesions. Columnar continuous specimens from the surface of the normal brain tissue to the tumor margin and the center of the lesion were obtained using the boring biopsy method. We used a catheter introducer with original modifications to create a cylindrical biopsy tool for surgery. Columnar continuous specimens were successfully obtained. Histopathological diagnosis was based on cellular changes and differentiation from normal tissues to the core of the lesion and established in all cases. No permanent deficits, major adverse outcomes, or deaths were observed. This novel technique may improve diagnostic accuracy and reduce invasiveness associated with brain biopsy. This method may become the next standard procedure, particularly in some cases where histological evaluation is paramount, and conventional biopsy methods are not suitable.
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Details
1 Shinshu University School of Medicine, Department of Neurosurgery, Matsumoto, Japan (GRID:grid.263518.b) (ISNI:0000 0001 1507 4692)
2 Kobayashi Neurosurgical Hospital, Department of Neurosurgery, Nagano, Japan (GRID:grid.263518.b)
3 Shinshu University School of Medicine, Department of Neurosurgery, Matsumoto, Japan (GRID:grid.263518.b) (ISNI:0000 0001 1507 4692); St. Marianna University School of Medicine, Department of Neurosurgery, Kawasaki, Japan (GRID:grid.412764.2) (ISNI:0000 0004 0372 3116)
4 Shinshu University Hospital, Department of Laboratory Medicine, Matsumoto, Japan (GRID:grid.412568.c) (ISNI:0000 0004 0447 9995)