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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation classified according to the WHO as nondestructive, polymorphic, monomorphic, and classic Hodgkin Lymphoma subtypes. In this retrospective study, we investigated the potential of semi-quantitative 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) PET/computed tomography (CT)-based parameters to differentiate between the PTLD morphological subtypes. Methods: 96 patients with histopathologically confirmed PTLD and baseline [18F]FDG PET/CT between 2009 and 2019 were included. Extracted semi-quantitative measurements included: Maximum, peak, and mean standardized uptake value (SUVmax, SUVpeak, and SUVmean). Results: Median SUVs were highest for monomorphic PTLD followed by polymorphic and nondestructive subtypes. The median SUVpeak at the biopsy site was significantly higher in monomorphic PTLD (17.8, interquartile range (IQR):16) than in polymorphic subtypes (9.8, IQR:13.4) and nondestructive (4.1, IQR:6.1) (p = 0.04 and p ≤ 0.01, respectively). An SUVpeak ≥ 24.8 was always indicative of a monomorphic PTLD in our dataset. Nevertheless, there was a considerable overlap in SUV across the different morphologies. Conclusion: The median SUVpeak at the biopsy site was significantly higher in monomorphic PTLD than polymorphic and nondestructive subtypes. However, due to significant SUV overlap across the different subtypes, these values may only serve as an indication of PTLD morphology, and SUV-based parameters cannot replace histopathological classification.

Details

Title
Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [18F]FDG PET/CT
Author
Filipe Montes de Jesus 1   VIAFID ORCID Logo  ; Vergote, Vibeke 2 ; Noordzij, Walter 1 ; Dierickx, Daan 2 ; Dierckx, Rudi 1 ; Diepstra, Arjan 3   VIAFID ORCID Logo  ; Tousseyn, Thomas 4 ; Gheysens, Olivier 5 ; Kwee, Thomas 6 ; Deroose, Christophe 7 ; Glaudemans, Andor 1   VIAFID ORCID Logo 

 Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; [email protected] (W.N.); [email protected] (R.D.); [email protected] (A.G.) 
 Department of Hematology, University Hospitals Leuven, 3000 Leuven, Belgium; [email protected] (V.V.); [email protected] (D.D.) 
 Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; [email protected] 
 Department of Pathology University Hospitals Leuven, 3000 Leuven, Belgium; [email protected] 
 Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium; [email protected] 
 Department of Radiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; [email protected] 
 Department of Nuclear Medicine, University Hospitals Leuven, 3000 Leuven, Belgium; [email protected] 
First page
361
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2641037280
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.