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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This study aimed to address the impact of 1-hr bundle achievement on outcomes in septic shock patients. Secondary analysis of multicenter prospectively collected data on septic shock patients who had undergone protocolized resuscitation bundle therapy at emergency departments was conducted. In-hospital mortality according to 1-h bundle achievement was compared using multivariable logistic regression analysis. Patients were also divided into 3 groups according to the time of bundle achievement and outcomes were compared to examine the difference in outcome for each group over time: group 1 (≤1 h reference), group 2 (1–3 h) and group 3 (3–6 h). In total, 1612 patients with septic shock were included. The 1-h bundle was achieved in 461 (28.6%) patients. The group that achieved the 1-h bundle did not show a significant difference in in-hospital mortality compared to the group that did not achieve the 1-h bundle on multivariable logistic regression analysis (<1 vs. >1 h) (odds ratio = 0.74, p = 0.091). However, 3- and 6- h bundle achievements showed significantly lower odds ratios of in-hospital mortality compared to the group that did not achieve the bundle (<3 vs. >3 h, <6 vs. >6 h, odds ratio = 0.604 and 0.458, respectively). There was no significant difference in in-hospital mortality over time for group 2 and 3 compared to that of group 1. One-hour bundle achievement was not associated with improved outcomes in septic shock patients. These data suggest that further investigation into the clinical implications of 1-h bundle achievement in patients with septic shock is warranted.

Details

Title
Impact of 1-Hour Bundle Achievement in Septic Shock
Author
Byuk Sung Ko 1 ; Choi, Sung-Hyuk 2   VIAFID ORCID Logo  ; Tae Gun Shin 3   VIAFID ORCID Logo  ; Kyuseok Kim 4   VIAFID ORCID Logo  ; You, Hwan Jo 5 ; Seung Mok Ryoo 6 ; Park, Yoo Seok 7 ; Woon Yong Kwon 8 ; Han Sung Choi 9 ; Sung, Phil Chung 10   VIAFID ORCID Logo  ; Suh, Gil Joon 8   VIAFID ORCID Logo  ; Kang, Hyunggoo 1   VIAFID ORCID Logo  ; Tae Ho Lim 1 ; Son, Donghee 11   VIAFID ORCID Logo  ; Won Young Kim 6   VIAFID ORCID Logo 

 Department of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea; [email protected] (B.S.K.); [email protected] (H.K.); [email protected] (T.H.L.) 
 Department of Emergency Medicine, Korea University Guro Hospital, Seoul 08308, Korea; [email protected] 
 Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea; [email protected] 
 Department of Emergency Medicine, CHA University School of Medicine, CHA Bundang Medical Center, Seongnam-si 13449, Gyeonggi-do, Korea; [email protected] 
 Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si 13620, Gyeonggi-do, Korea; [email protected] 
 Department of Emergency Medicine, College of Medicine, Asan Medical Center, University of Ulsan, Seoul 05505, Korea; [email protected] 
 Department of Emergency Medicine, Yonsei University College of Medicine, Seoul 03722, Korea; [email protected] 
 Department of Emergency Medicine, Seoul National University Hospital, Seoul 03080, Korea; [email protected] (W.Y.K.); [email protected] (G.J.S.) 
 Department of Emergency Medicine, Kyung Hee University Hospital, Seoul 02453, Korea; [email protected] 
10  Department of Emergency Medicine, Gangnam Severance Hospital, Seoul 06273, Korea; [email protected] 
11  Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul 04763, Korea; [email protected] 
First page
527
Publication year
2021
Publication date
2021
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2641045247
Copyright
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.