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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Introduction: Arterial hypertension is the most frequent cause for spontaneous intracerebral hemorrhage (sICH) and may also cause left ventricular hypertrophy (LVH). We sought to analyze whether hypertensive sICH etiology is associated with LVH. Methods: We analyzed consecutive patients with sICH who were admitted to our tertiary stroke center during a four-year period and underwent transthoracic echocardiography (TTE) as part of the diagnostic work-up. We defined hypertensive sICH as typical localization of hemorrhage in patients with arterial hypertension and no other identified sICH etiology. We defined an increased end-diastolic interventricular septal wall thickness of ≥11 mm on TTE as a surrogate parameter for LVH. Results: Among 395 patients with sICH, 260 patients (65.8%) received TTE as part of their diagnostic work-up. The median age was 71 years (interquartile range (IQR) 17), 160 patients (61.5%) were male, the median baseline National Institute of Health Stroke Scale (NIHSS) score was 8 (IQR 13). Of these, 159 (61.2%) patients had a hypertensive sICH and 156 patients (60%) had LVH. In univariable (113/159 (71.1%) vs. 43/101 (42.6%); odds ratio (OR) 3.31; 95% confidence interval (CI95%) 1.97–5.62); and multivariable (adjusted OR 2.95; CI95% 1.29–6.74) analysis, hypertensive sICH was associated with LVH. Conclusions: In patients with sICH, LVH is associated with hypertensive bleeding etiology. Performing TTE is meaningful for diagnosis of comorbidities and clarification of bleeding etiology in these patients. Future studies should include long-term outcome parameters and assess left ventricular mass as main indicator for LVH.

Details

Title
Association of Hypertensive Intracerebral Hemorrhage with Left Ventricular Hypertrophy on Transthoracic Echocardiography
Author
Pallesen, Lars-Peder 1   VIAFID ORCID Logo  ; Wagner, Jenny 1 ; Lambrou, Dimitris 2 ; Braun, Silke 3 ; Weise, Matthias 4 ; Prakapenia, Alexandra 1 ; Barlinn, Jessica 1 ; Siepmann, Timo 1 ; Winzer, Simon 1 ; Haidar Moustafa 1 ; Kitzler, Hagen H 5 ; Barlinn, Kristian 1 ; Heinz Reichmann 6 ; Puetz, Volker 1 

 Dresden Neurovascular Center, Department of Neurology, Dresden University of Technology, 01307 Dresden, Germany; [email protected] (J.W.); [email protected] (A.P.); [email protected] (J.B.); [email protected] (T.S.); [email protected] (S.W.); [email protected] (H.M.); [email protected] (K.B.); [email protected] (H.R.); [email protected] (V.P.) 
 Department of Medicine, University of Thessaly, 41500 Larissa, Greece; [email protected] 
 Medical Clinic I, Dresden University of Technology, 01307 Dresden, Germany; [email protected] 
 Medical Clinic III, Dresden University of Technology, 01307 Dresden, Germany; [email protected] 
 Institute of Diagnostic and Interventional Neuroradiology, Dresden University of Technology, 01307 Dresden, Germany; [email protected] 
 Dresden Neurovascular Center, Department of Neurology, Dresden University of Technology, 01307 Dresden, Germany; [email protected] (J.W.); [email protected] (A.P.); [email protected] (J.B.); [email protected] (T.S.); [email protected] (S.W.); [email protected] (H.M.); [email protected] (K.B.); [email protected] (H.R.); [email protected] (V.P.), Heinz Reichmann 
First page
2148
Publication year
2020
Publication date
2020
Publisher
MDPI AG
e-ISSN
20770383
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2641063300
Copyright
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.