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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

This study examined the efficacy of curcumin (Cur) against lead (Pb)-induced oxidative damage, inflammation, and cholinergic dysfunction. Institute for Cancer Research (ICR) mice received Pb (II) acetate in drinking water (1%) with or without Cur via oral gavage. Blood and brain tissues were collected for investigation. Pb increased the inflammatory markers and oxidative parameters, which were ameliorated by Cur administration. Cur treatment also improved memory loss, learning deficit, and cholinergic dysfunction via elevating acetylcholinesterase (AChE) enzymatic activity and protein expression. In silico molecular docking supported the results; Cur had a potent binding affinity for AChE receptors, tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), phosphorylations of IκB kinase (IKK), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38). According to the chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile, Cur could serve as a potential candidate for Pb detoxication substance via exerting antioxidant activity. Taken together, our results suggest that Cur is a natural compound that could be used for the treatment of neurodegenerative disorders via suppressing lead-induced neurotoxicity.

Details

Title
Curcumin Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In Silico Molecular Docking
Author
Changlek, Suksan 1 ; Rana, Mohammad Nasiruddin 2 ; Moe, Pwint Phyu 3 ; Naymul Karim 4   VIAFID ORCID Logo  ; Majima, Hideyuki J 1   VIAFID ORCID Logo  ; Tangpong, Jitbanjong 1 

 Biomedical Sciences, School of Allied Health Sciences, Walailak University, Thai Buri 80160, Thailand; [email protected] (S.C.); [email protected] (M.N.R.); [email protected] (M.P.P.); [email protected] (N.K.); [email protected] (H.J.M.); Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Walailak University, Thai Buri 80160, Thailand 
 Biomedical Sciences, School of Allied Health Sciences, Walailak University, Thai Buri 80160, Thailand; [email protected] (S.C.); [email protected] (M.N.R.); [email protected] (M.P.P.); [email protected] (N.K.); [email protected] (H.J.M.); Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University, Hangzhou 310058, China 
 Biomedical Sciences, School of Allied Health Sciences, Walailak University, Thai Buri 80160, Thailand; [email protected] (S.C.); [email protected] (M.N.R.); [email protected] (M.P.P.); [email protected] (N.K.); [email protected] (H.J.M.) 
 Biomedical Sciences, School of Allied Health Sciences, Walailak University, Thai Buri 80160, Thailand; [email protected] (S.C.); [email protected] (M.N.R.); [email protected] (M.P.P.); [email protected] (N.K.); [email protected] (H.J.M.); College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China 
First page
856
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
23048158
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2642398668
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.