Abstract

The identification of acquired resistance mutations has been essential in non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) active mutations. Rebiopsy plays a pivotal role in selecting the optimal treatment for patients who develop resistance to initial EGFR-tyrosine kinase inhibitors (EGFR-TKIs). This multicenter, observational study was conducted to investigate the details of rebiopsy in Japanese clinical practice. The primary endpoints were the implementation rate of rebiopsy and the concordance rate for T790M mutation detection between histological and cytological specimens using the cobas EGFR Mutation Test, version 2. One hundred ninety-four patients with EGFR-mutant NSCLC were enrolled, and 120 patients developed acquired resistance to EGFR-TKIs. The median age was 68 years (range 20–87), and 52.5% of the patients were women. Rebiopsy was performed in 109 patients, and the implementation rate of rebiopsy was 90.8%. The success rates of rebiopsy in the total, histology, cytology and liquid biopsy populations were 67.9%, 81.3%, 66.7% and 43.8%, respectively. The positive percent agreement and the negative percent agreement in the detection of the T790M mutation between the histological and cytological specimens were both 90.9%. Obtaining histological or cytological tissue samples at rebiopsy may contribute to improving the detection rate of the T790M mutation (trial registration number: UMIN000026019).

Details

Title
Observational study of rebiopsy in EGFR-TKI-resistant patients with EGFR mutation-positive advanced NSCLC
Author
Koyama Kenichi 1 ; Miura Satoru 1 ; Watanabe, Satoshi 2 ; Shoji Satoshi 2 ; Koshio Jun 3 ; Hayashi Yoshiki 4 ; Ishikawa Daisuke 5 ; Sato, Ko 6 ; Miyabayashi Takao 7 ; Okajima Masaaki 8 ; Ota Takeshi 9 ; Tanaka, Tomohiro 2 ; Matsumoto Naoya 10 ; Kuriyama Hideyuki 11 ; Abe, Tetsuya 12 ; Nozaki Koichiro 2 ; Ichikawa Kosuke 13 ; Kondo Rie 2 ; Tanaka, Hiroshi 1 ; Kikuchi Toshiaki 2 

 Niigata Cancer Center Hospital, Department of Internal Medicine, Niigata city, Japan (GRID:grid.416203.2) (ISNI:0000 0004 0377 8969) 
 Niigata University Graduate School of Medical and Dental Sciences, Department of Respiratory Medicine and Infectious Diseases, Chuouku, Niigata, Japan (GRID:grid.260975.f) (ISNI:0000 0001 0671 5144) 
 Nagaoka Red Cross Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416384.c) (ISNI:0000 0004 1774 7290) 
 Nagaoka Chuo General Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416384.c) 
 Niigata Prefectural Central Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416207.6) (ISNI:0000 0004 0596 6277); Sado General Hospital, Department of Respiratory Medicine, Sado, Japan (GRID:grid.452773.0) 
 Niigata Prefectural Central Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416207.6) (ISNI:0000 0004 0596 6277); Tsuruoka Municipal Shonai Hospital, Department of Respiratory Medicine, Tsuruoka, Japan (GRID:grid.416207.6) 
 Niigata City General Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416205.4) (ISNI:0000 0004 1764 833X) 
 Saiseikai Niigata Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416205.4) 
 Shibata Hospital - Niigata Prefectural Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416205.4) 
10  Nishi Niigata Chuo Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.260975.f) 
11  Niigata Medical Center, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.260975.f) 
12  Niigata City General Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.416205.4) (ISNI:0000 0004 1764 833X); Shinrakuen Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.415782.d) (ISNI:0000 0001 0091 3414) 
13  Saiseikai Niigata Hospital, Department of Respiratory Medicine, Niigata, Japan (GRID:grid.260975.f) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2650970738
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.