Abstract

Background

Low back pain is a disability that occurs worldwide. It is a heterogeneous disorder that affects patients with dominant nociceptive, neuropathic, and central sensitization pain. An important pathophysiology of low back pain involves pain sensitization. Various nonoperative interventions are available for treatment, but there is inconclusive evidence on the effectiveness of these interventions for pain sensitization, leading to arbitrary nonoperative treatments for low back pain.

Methods

We will conduct a systematic review of RCTs evaluating the effectiveness and safety of nonoperative treatment for pain sensitization in patients with low back pain. The primary outcomes will be static quantitative sensory testing, dynamic quantitative sensory testing, and pain algometry. The secondary outcome will be adverse events. We will search the PubMed, Embase, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), and Cochrane Library databases. Two independent authors will screen the titles and abstracts, review full texts, extract data, assess the risk of bias, and evaluate the quality of evidence. We will qualitatively and quantitatively synthesize the results using a random effects model for meta-analysis.

Discussion

This systematic review aims to provide evidence regarding which treatment, if any, provides the greatest benefit for pain sensitization and safety among patients with low back pain. Evidence synthesized from this systematic review will inform clinical practice and further research. Since there is still a small amount of research, additional studies might need to be conducted in the future.

Systematic review registration

Submitted to PROSPERO on March 20, 2021, CRD42021244054

Details

Title
Nonoperative treatment for pain sensitization in patients with low back pain: protocol for a systematic review
Author
Nopsopon, Tanawin  VIAFID ORCID Logo  ; Suputtitada, Areerat  VIAFID ORCID Logo  ; Lertparinyaphorn, Irin  VIAFID ORCID Logo  ; Pongpirul, Krit  VIAFID ORCID Logo 
Pages
1-7
Section
Systematic review update
Publication year
2022
Publication date
2022
Publisher
BioMed Central
e-ISSN
20464053
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2652037685
Copyright
© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.