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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The mechanism of tinnitus accompanied by a normal audiogram remains elusive. This study aimed to investigate evidence of primary neural degeneration, also known as cochlear synaptopathy, in tinnitus patients with normal hearing thresholds. We analyzed the differences in electrocochleography (ECochG) measurements between normal-hearing subjects with and without tinnitus. Forty-five subjects were enrolled in this study: 21 were in the tinnitus group, defined by chronic tinnitus of over two months’ duration with normal audiometric thresholds, and 24 were in the control group, defined by a lack of tinnitus complaints. Electrocochleograms were evoked by 1, 4, 6, and 8 kHz alternating-polarity tone bursts at sound pressure levels (SPLs) of 90–110 dB. The tinnitus group had smaller action potential (AP) amplitudes than the control group for 1, 4, 6, and 8 kHz tone bursts and showed significant amplitude reduction at 1 kHz 110 dB SPL (p < 0.01), 1 kHz 90 dB SPL (p < 0.05), and 4 kHz 110 dB SPL (p < 0.05). There were no significant differences in the summating potential/action potential (SP/AP) amplitude ratios across the four tested frequencies. A trend of reduced AP amplitudes was found in the tinnitus group, supporting the hypothesis that tinnitus might be associated with primary neural degeneration.

Details

Title
Are Electrocochleographic Changes an Early Sign of Cochlear Synaptopathy? A Prospective Study in Tinnitus Patients with Normal Hearing
Author
Kuan-Chung, Ting 1   VIAFID ORCID Logo  ; Chia-Chen, Chang 2 ; Chii-Yuan Huang 3   VIAFID ORCID Logo  ; Yu-Fu, Chen 2 ; Yen-Fu, Cheng 4   VIAFID ORCID Logo 

 Department of Otolaryngology—Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan; [email protected] (K.-C.T.); [email protected] (C.-Y.H.); Department of Otolaryngology, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan 
 Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan; [email protected] (C.-C.C.); [email protected] (Y.-F.C.) 
 Department of Otolaryngology—Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan; [email protected] (K.-C.T.); [email protected] (C.-Y.H.); Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan 
 Department of Otolaryngology—Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan; [email protected] (K.-C.T.); [email protected] (C.-Y.H.); Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Department of Speech-Language Pathology and Audiology, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan; [email protected] (C.-C.C.); [email protected] (Y.-F.C.); Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan 
First page
802
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20754418
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2652970320
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.