Abstract

Primary liver cancer mainly includes the following four types: hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CCA). Recent studies have indicated that there are differences in cancer stem cell (CSC) properties among different types of liver cancer. Liver cancer stem cells (LCSCs), also called liver tumor-initiating cells, have been viewed as drivers of tumor initiation and metastasis. Many mechanisms and factors, such as mitophagy, mitochondrial dynamics, epigenetic modifications, the tumor microenvironment, and tumor plasticity, are involved in the regulation of cancer stemness in liver cancer. In this review, we analyze cancer stemness in different liver cancer types. Moreover, we further evaluate the mechanism of cancer stemness maintenance of LCSCs and discuss promising treatments for eradicating LCSCs.

Details

Title
Mechanism of cancer stemness maintenance in human liver cancer
Author
Liang, Ning 1   VIAFID ORCID Logo  ; Yang, Tao 2 ; Huang, Qian 3 ; Yu, Pengfei 4 ; Liu Chaoxu 5 ; Chen, Liusheng 6 ; Wang, Qian 7   VIAFID ORCID Logo  ; Wang, Gang 8   VIAFID ORCID Logo  ; He Xianli 9   VIAFID ORCID Logo 

1  Tangdu Hospital, Air Force Military Medical University, Department of General Surgery, Xi’an, China (GRID:grid.460007.5) (ISNI:0000 0004 1791 6584); The 75th Group Army Hospital, Department of General Surgery, Dali, China (GRID:grid.460007.5) 
2  Tangdu Hospital, Air Force Military Medical University, Department of Pain Treatment, Xi’an, China (GRID:grid.460007.5) (ISNI:0000 0004 1791 6584) 
3  The 75th Group Army Hospital, Department of Obstetrics and Gynecology, Dali, China (GRID:grid.460007.5) 
4  Xijing Hospital of Digestive Diseases, Air Force Military Medical University, State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases, Xi’an, China (GRID:grid.417295.c) (ISNI:0000 0004 1799 374X) 
5  the First Affiliated Hospital of Zhejiang University, Department of General Surgery, Hangzhou, China (GRID:grid.452661.2) (ISNI:0000 0004 1803 6319) 
6  Clinical Medical Research Center, The 75th Group Army Hospital, Dali, China (GRID:grid.452661.2) 
7  Zhengzhou University, Department of Anorectal Surgery, The First Affiliated Hospital, Zhengzhou, China (GRID:grid.207374.5) (ISNI:0000 0001 2189 3846) 
8  the 74th group army hospital, Department of General Surgery, Guangzhou, China (GRID:grid.207374.5) 
9  Tangdu Hospital, Air Force Military Medical University, Department of General Surgery, Xi’an, China (GRID:grid.460007.5) (ISNI:0000 0004 1791 6584) 
Publication year
2022
Publication date
Apr 2022
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-022-04848-z
ProQuest document ID
2653037302
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.