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Abstract
Increasing studies have demonstrated the association between heavy metal pollution and micronutrients, especially folate. However, the relationship between cadmium and folate remains rarely discussed. In this study, we aim to explore the potential correlation between cadmium and folate in human population and highlight the possible mechanism of cadmium impacting human health. We utilized the National Health and Nutrition Examination Survey (NHANES) 2017–2018 data with 5690 participants in this study. Multivariable linear regression models were adopted to investigate the serum lead and cadmium levels and RBC folate concentration. A significant reverse relationship was found between serum lead and cadmium and RBC folate. A negative relationship between serum lead and cadmium levels and the levels of RBC folate in the U.S. adult population was found in this study. Nevertheless, due to the general limitations of the NHANES data, as a cross-sectional study, a further prospective investigation is needed to discover the causality of lead and cadmium in folate status and to determine whether the folate supplement has a beneficial influence against heavy metal toxicities.
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Details
1 National Defense Medical Center, Department of Anesthesiology, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, ROC (GRID:grid.260565.2) (ISNI:0000 0004 0634 0356); National Defense Medical Center, Department of Internal Medicine, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, ROC (GRID:grid.260565.2) (ISNI:0000 0004 0634 0356)
2 National Defense Medical Center, Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, ROC (GRID:grid.260565.2) (ISNI:0000 0004 0634 0356); National Defense Medical Center, Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan, ROC (GRID:grid.260565.2) (ISNI:0000 0004 0634 0356); National Defense Medical Center, Department of Biochemistry, Taipei, Taiwan, ROC (GRID:grid.260565.2) (ISNI:0000 0004 0634 0356)