Abstract

The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.

Details

Title
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism
Author
Espinosa-Salinas, Isabel 1 ; Colmenarejo Gonzalo 1   VIAFID ORCID Logo  ; Fernández-Díaz, Cristina M 1 ; Gómez de Cedrón Marta 1   VIAFID ORCID Logo  ; Alfredo, Martinez J 2 ; Reglero Guillermo 3 ; Ramírez de Molina Ana 1   VIAFID ORCID Logo 

1  IMDEA-Food Institute, CEI UAM+CSIC, Madrid, Spain (GRID:grid.482878.9) (ISNI:0000 0004 0500 5302) 
2  IMDEA-Food Institute, CEI UAM+CSIC, Madrid, Spain (GRID:grid.482878.9) (ISNI:0000 0004 0500 5302); Navarra Institute for Health Research (IdiSNA), Center for Nutrition Research (CIN), Pamplona, Spain (GRID:grid.508840.1) (ISNI:0000 0004 7662 6114); Institute of Health Carlos III, Center of Biomedical Research in Physiopathology of Obesity and Nutrition (CIBEROBN), Madrid, Spain (GRID:grid.413448.e) (ISNI:0000 0000 9314 1427) 
3  IMDEA-Food Institute, CEI UAM+CSIC, Madrid, Spain (GRID:grid.482878.9) (ISNI:0000 0004 0500 5302); CEI UAM+CSIC, Institute of Food Science Research (CIAL), Madrid, Spain (GRID:grid.473520.7) (ISNI:0000 0004 0580 7575) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-022-10923-4
ProQuest document ID
2659408536
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.