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Abstract
Quantitative muscle MRI (water-T2 and fat mapping) is being increasingly used to assess disease involvement in muscle disorders, while imaging techniques for assessment of the dynamic and elastic muscle properties have not yet been translated into clinics. In this exploratory study, we quantitatively characterized muscle deformation (strain) in patients affected by facioscapulohumeral muscular dystrophy (FSHD), a prevalent muscular dystrophy, by applying dynamic MRI synchronized with neuromuscular electrical stimulation (NMES). We evaluated the quadriceps muscles in 34 ambulatory patients and 13 healthy controls, at 6-to 12-month time intervals. While a subgroup of patients behaved similarly to controls, for another subgroup the median strain decreased over time (approximately 57% over 1.5 years). Dynamic MRI parameters did not correlate with quantitative MRI. Our results suggest that the evaluation of muscle contraction by NMES-MRI is feasible and could potentially be used to explore the elastic properties and monitor muscle involvement in FSHD and other neuromuscular disorders.
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Details
1 University Hospital of Basel, Radiology, Division of Radiological Physics, Basel, Switzerland (GRID:grid.410567.1); University of Basel, Basel Muscle MRI, Department of Biomedical Engineering, Allschwil, Switzerland (GRID:grid.6612.3) (ISNI:0000 0004 1937 0642)
2 IRCCS Mondino Foundation, Neuroradiology Department, Advanced Imaging and Radiomics Center, Pavia, Italy (GRID:grid.419416.f) (ISNI:0000 0004 1760 3107)
3 University of Insubria, School of Specialization in Clinical Pharmacology and Toxicology Center of Research in Medical Pharmacology, School of Medicine, Varese, Italy (GRID:grid.18147.3b) (ISNI:0000000121724807)
4 Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, Department of Neurology, Buffalo, USA (GRID:grid.273335.3) (ISNI:0000 0004 1936 9887); IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy (GRID:grid.418563.d) (ISNI:0000 0001 1090 9021)
5 Fondazione Policlinico Universitario A. Gemelli IRCCS, Unità Operativa Complessa di Neurologia, Rome, Italy (GRID:grid.414603.4)
6 IRCCS Mondino Foundation, Neuroradiology Department, Advanced Imaging and Radiomics Center, Pavia, Italy (GRID:grid.419416.f) (ISNI:0000 0004 1760 3107); University of Pavia, Department of Brain and Behavioral Sciences, Pavia, Italy (GRID:grid.8982.b) (ISNI:0000 0004 1762 5736)