Details
Title
Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study
Author
García-Martín Paloma 1 ; Díez, Ana Moñiz 2 ; Maldonado José Manuel Sánchez 2 ; Serrano Antonio José Cabrera 2 ; ter Horst Rob 3 ; Benavente Yolanda 4 ; Landi Stefano 5
; Macauda Angelica 6 ; Clay-Gilmour, Alyssa 7 ; Hernández-Mohedo Francisca 8 ; Niazi Yasmeen 9 ; González-Sierra, Pedro 8
; Espinet Blanca 10
; Rodríguez-Sevilla, Juan José 11 ; Maffei Rossana 12
; Blanco Gonzalo 10
; Giaccherini Matteo 5 ; Puiggros Anna 10 ; Cerhan, James 13
; Marasca Roberto 12
; Cañadas-Garre Marisa 2
; López-Nevot, Miguel Ángel 14 ; Chen-Liang, Tzu 15
; Thomsen Hauke 16
; Gámez Irene 15 ; Moreno, Víctor 17
; Marcos-Gragera, Rafael 18 ; García-Álvarez María 19 ; Llorca Javier 20 ; Jerez Andrés 15 ; Berndt, Sonja 21 ; Butrym Aleksandra 22 ; Norman, Aaron D 13 ; Casabonne Delphine 4 ; Luppi, Mario 12 ; Slager, Susan L 23
; Hemminki Kari 24 ; Yang, Li 25 ; Alcoceba Miguel 26
; Campa Daniele 5 ; Canzian Federico 6
; de Sanjosé Silvia 4 ; Försti Asta 9 ; Netea, Mihai G 27
; Jurado, Manuel 2 ; Sainz, Juan 28
1 Hospital Campus de la Salud, PTS Granada, Granada, Spain (GRID:grid.418805.0) (ISNI:0000 0004 0500 8423)
2 Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Genomic Oncology Area, GENYO, Granada, Spain (GRID:grid.418805.0) (ISNI:0000 0004 0500 8423); Virgen de las Nieves University Hospital, Hematology department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain (GRID:grid.507088.2)
3 Radboud University Medical Center, Department of Internal Medicine and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands (GRID:grid.10417.33) (ISNI:0000 0004 0444 9382); CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (GRID:grid.418729.1) (ISNI:0000 0004 0392 6802)
4 Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) and University of Barcelona, Barcelona, Spain (GRID:grid.418284.3) (ISNI:0000 0004 0427 2257); CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246)
5 University of Pisa, Department of Biology, Pisa, Italy (GRID:grid.5395.a) (ISNI:0000 0004 1757 3729)
6 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany (GRID:grid.7497.d) (ISNI:0000 0004 0492 0584)
7 University of South Carolina, Department of Epidemiology & Biostatistics, Arnold School of Public Health, Greenville, USA (GRID:grid.254567.7) (ISNI:0000 0000 9075 106X)
8 Virgen de las Nieves University Hospital, Hematology department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain (GRID:grid.507088.2)
9 German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany (GRID:grid.7497.d) (ISNI:0000 0004 0492 0584); Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany (GRID:grid.510964.f)
10 Hospital del Mar, Molecular Cytogenetics Laboratory, Pathology Department, Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811); Cancer Research Program, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Translational Research on Hematological Neoplasms Group, Barcelona, Spain (GRID:grid.20522.37) (ISNI:0000 0004 1767 9005)
11 Hospital del Mar, Hematology Department, Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811)
12 University of Modena and Reggio Emilia, AOU Policlinico, Department of Medical and Surgical Sciences, Modena, Italy (GRID:grid.7548.e) (ISNI:0000000121697570)
13 Mayo Clinic, Department of Quantitative Health Sciences, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
14 Virgen de las Nieves University Hospital, Immunology Department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783)
15 Morales Meseguer University Hospital, Hematology Department, Murcia, Spain (GRID:grid.411372.2) (ISNI:0000 0001 0534 3000)
16 ProtaGene CGT GmbH, Heidelberg, Germany (GRID:grid.411372.2)
17 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Barcelona, Unit of Biomarkers and Susceptibility, Cancer Prevention and Control Program, IDIBELL, Catalan Institute of Oncology; Department of Clinical Sciences, Faculty of Medicine, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)
18 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), and Universitat de Girona, Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Girona, Spain (GRID:grid.466571.7); Josep Carreras Leukemia Research Institute, Girona, Spain (GRID:grid.429289.c)
19 University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Institute of Salamanca-IBMCC (USAL-CSIC), Department of Hematology, Salamanca, Spain (GRID:grid.411258.b)
20 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Cantabria, Santander, Spain (GRID:grid.7821.c) (ISNI:0000 0004 1770 272X)
21 National Institutes of Health, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA (GRID:grid.94365.3d) (ISNI:0000 0001 2297 5165)
22 Medical University of Wrocław, Wrocław, Poland (GRID:grid.4495.c) (ISNI:0000 0001 1090 049X)
23 Mayo Clinic, Division of Computational Genomics, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X); Mayo Clinic, Division of Hematology, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
24 German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany (GRID:grid.7497.d) (ISNI:0000 0004 0492 0584); Charles University in Prague, Faculty of Medicine and Biomedical Center in Pilsen, Pilsen, Czech Republic (GRID:grid.4491.8) (ISNI:0000 0004 1937 116X)
25 Radboud University Medical Center, Department of Internal Medicine and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands (GRID:grid.10417.33) (ISNI:0000 0004 0444 9382); joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Centre for Individualised Infection Medicine (CiiM) & TWINCORE, Hannover, Germany (GRID:grid.512472.7)
26 Josep Carreras Leukemia Research Institute, Girona, Spain (GRID:grid.429289.c)
27 Radboud University Medical Center, Department of Internal Medicine and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands (GRID:grid.10417.33) (ISNI:0000 0004 0444 9382); University of Bonn, Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), Bonn, Germany (GRID:grid.10388.32) (ISNI:0000 0001 2240 3300)
28 Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Genomic Oncology Area, GENYO, Granada, Spain (GRID:grid.418805.0) (ISNI:0000 0004 0500 8423); Virgen de las Nieves University Hospital, Hematology department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain (GRID:grid.507088.2); University of Granada (UGR), Department of Biochemistry and Molecular Biology I, Faculty of Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994)
; Macauda Angelica 6 ; Clay-Gilmour, Alyssa 7 ; Hernández-Mohedo Francisca 8 ; Niazi Yasmeen 9 ; González-Sierra, Pedro 8
; Espinet Blanca 10
; Rodríguez-Sevilla, Juan José 11 ; Maffei Rossana 12
; Blanco Gonzalo 10
; Giaccherini Matteo 5 ; Puiggros Anna 10 ; Cerhan, James 13
; Marasca Roberto 12
; Cañadas-Garre Marisa 2
; López-Nevot, Miguel Ángel 14 ; Chen-Liang, Tzu 15
; Thomsen Hauke 16
; Gámez Irene 15 ; Moreno, Víctor 17
; Marcos-Gragera, Rafael 18 ; García-Álvarez María 19 ; Llorca Javier 20 ; Jerez Andrés 15 ; Berndt, Sonja 21 ; Butrym Aleksandra 22 ; Norman, Aaron D 13 ; Casabonne Delphine 4 ; Luppi, Mario 12 ; Slager, Susan L 23
; Hemminki Kari 24 ; Yang, Li 25 ; Alcoceba Miguel 26
; Campa Daniele 5 ; Canzian Federico 6
; de Sanjosé Silvia 4 ; Försti Asta 9 ; Netea, Mihai G 27
; Jurado, Manuel 2 ; Sainz, Juan 28
1 Hospital Campus de la Salud, PTS Granada, Granada, Spain (GRID:grid.418805.0) (ISNI:0000 0004 0500 8423)
2 Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Genomic Oncology Area, GENYO, Granada, Spain (GRID:grid.418805.0) (ISNI:0000 0004 0500 8423); Virgen de las Nieves University Hospital, Hematology department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain (GRID:grid.507088.2)
3 Radboud University Medical Center, Department of Internal Medicine and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands (GRID:grid.10417.33) (ISNI:0000 0004 0444 9382); CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (GRID:grid.418729.1) (ISNI:0000 0004 0392 6802)
4 Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) and University of Barcelona, Barcelona, Spain (GRID:grid.418284.3) (ISNI:0000 0004 0427 2257); CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246)
5 University of Pisa, Department of Biology, Pisa, Italy (GRID:grid.5395.a) (ISNI:0000 0004 1757 3729)
6 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany (GRID:grid.7497.d) (ISNI:0000 0004 0492 0584)
7 University of South Carolina, Department of Epidemiology & Biostatistics, Arnold School of Public Health, Greenville, USA (GRID:grid.254567.7) (ISNI:0000 0000 9075 106X)
8 Virgen de las Nieves University Hospital, Hematology department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain (GRID:grid.507088.2)
9 German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany (GRID:grid.7497.d) (ISNI:0000 0004 0492 0584); Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany (GRID:grid.510964.f)
10 Hospital del Mar, Molecular Cytogenetics Laboratory, Pathology Department, Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811); Cancer Research Program, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Translational Research on Hematological Neoplasms Group, Barcelona, Spain (GRID:grid.20522.37) (ISNI:0000 0004 1767 9005)
11 Hospital del Mar, Hematology Department, Barcelona, Spain (GRID:grid.411142.3) (ISNI:0000 0004 1767 8811)
12 University of Modena and Reggio Emilia, AOU Policlinico, Department of Medical and Surgical Sciences, Modena, Italy (GRID:grid.7548.e) (ISNI:0000000121697570)
13 Mayo Clinic, Department of Quantitative Health Sciences, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
14 Virgen de las Nieves University Hospital, Immunology Department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783)
15 Morales Meseguer University Hospital, Hematology Department, Murcia, Spain (GRID:grid.411372.2) (ISNI:0000 0001 0534 3000)
16 ProtaGene CGT GmbH, Heidelberg, Germany (GRID:grid.411372.2)
17 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Barcelona, Unit of Biomarkers and Susceptibility, Cancer Prevention and Control Program, IDIBELL, Catalan Institute of Oncology; Department of Clinical Sciences, Faculty of Medicine, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)
18 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), and Universitat de Girona, Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Girona, Spain (GRID:grid.466571.7); Josep Carreras Leukemia Research Institute, Girona, Spain (GRID:grid.429289.c)
19 University Hospital of Salamanca (HUS/IBSAL), CIBERONC and Cancer Research Institute of Salamanca-IBMCC (USAL-CSIC), Department of Hematology, Salamanca, Spain (GRID:grid.411258.b)
20 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain (GRID:grid.466571.7) (ISNI:0000 0004 1756 6246); University of Cantabria, Santander, Spain (GRID:grid.7821.c) (ISNI:0000 0004 1770 272X)
21 National Institutes of Health, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA (GRID:grid.94365.3d) (ISNI:0000 0001 2297 5165)
22 Medical University of Wrocław, Wrocław, Poland (GRID:grid.4495.c) (ISNI:0000 0001 1090 049X)
23 Mayo Clinic, Division of Computational Genomics, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X); Mayo Clinic, Division of Hematology, Rochester, USA (GRID:grid.66875.3a) (ISNI:0000 0004 0459 167X)
24 German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany (GRID:grid.7497.d) (ISNI:0000 0004 0492 0584); Charles University in Prague, Faculty of Medicine and Biomedical Center in Pilsen, Pilsen, Czech Republic (GRID:grid.4491.8) (ISNI:0000 0004 1937 116X)
25 Radboud University Medical Center, Department of Internal Medicine and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands (GRID:grid.10417.33) (ISNI:0000 0004 0444 9382); joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Centre for Individualised Infection Medicine (CiiM) & TWINCORE, Hannover, Germany (GRID:grid.512472.7)
26 Josep Carreras Leukemia Research Institute, Girona, Spain (GRID:grid.429289.c)
27 Radboud University Medical Center, Department of Internal Medicine and Radboud Center for Infectious Diseases, Nijmegen, The Netherlands (GRID:grid.10417.33) (ISNI:0000 0004 0444 9382); University of Bonn, Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), Bonn, Germany (GRID:grid.10388.32) (ISNI:0000 0001 2240 3300)
28 Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, Genomic Oncology Area, GENYO, Granada, Spain (GRID:grid.418805.0) (ISNI:0000 0004 0500 8423); Virgen de las Nieves University Hospital, Hematology department, Granada, Spain (GRID:grid.411380.f) (ISNI:0000 0000 8771 3783); Instituto de Investigación Biosanitaria IBs.Granada, Granada, Spain (GRID:grid.507088.2); University of Granada (UGR), Department of Biochemistry and Molecular Biology I, Faculty of Sciences, Granada, Spain (GRID:grid.4489.1) (ISNI:0000000121678994)
Publication year
2022
Publication date
May 2022
e-ISSN
20445385
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2665413955
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.