Abstract

Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.

Details

Title
Non-AUG translation initiation in mammals
Author
Andreev, Dmitry E; Loughran, Gary; Fedorova, Alla D; Mikhaylova, Maria S; Shatsky, Ivan N; Baranov, Pavel V  VIAFID ORCID Logo 
Pages
1-17
Section
Review
Publication year
2022
Publication date
2022
Publisher
Springer Nature B.V.
ISSN
14747596
e-ISSN
1474760X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s13059-022-02674-2
ProQuest document ID
2666608369
Copyright
© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.