Abstract

This study assessed the effect of magnifying endoscopy with narrow-band imaging (M-NBI) on the endoscopic differential diagnosis between intramucosal gastric carcinomas and adenomas with matched characteristics. Associations between magnified endoscopic findings and pathological high-grade cellular and architectural atypia were also investigated. In total, the records of 50 adenomas and 50 intramucosal well-differentiated adenocarcinomas matched by tumor size (≥ 20 mm or < 20 mm), shape (depression or non-depression), and color (red or non-red) were extracted. Fourteen endoscopists diagnosed adenoma or cancer in the 100 cases with conventional white light imaging (C-WLI), then did the same with C-WLI + M-NBI.The cancer diagnostic sensitivity, specificity, and accuracy were assessed. The sensitivity of C-WLI + M-NBI for cancer diagnosis was 79.9% compared to 71.6% with C-WLI (p < 0.001). There were no significant differences in specificity (40.1% vs. 36.3%, p = 0.296) and accuracy (55.9% vs. 58.1%, p = 0.163). High-grade cytological or architectural atypia was diagnosed more often with irregular microvascular pattern (IMVP) or microsurface pattern (IMSP), respectively, than the low-grade forms. In conclusion, IMVP and IMSP correlate with high-grade cytological and architectural atypia. M-NBI is useful in differentiating intramucosal carcinoma from adenoma and can reduce underdiagnosis of cancer.

Details

Title
Magnifying endoscopy with narrow-band imaging is useful in differentiating gastric cancer from matched adenoma in white light imaging
Author
Tamura Naoki 1 ; Sakaguchi Yoshiki 1 ; Furutani Wakiko 1 ; Matsui Maki 1 ; Nagao Sayaka 1 ; Sakuma Nobuyuki 1 ; Fukagawa Kazushi 1 ; Miura Yuko 1 ; Mizutani Hiroya 1 ; Ohki Daisuke 1 ; Kataoka Yosuke 1 ; Saito Itaru 1 ; Ono Masayoshi 2 ; Minatsuki Chihiro 1 ; Tsuji Yosuke 1 ; Ono Satoshi 1 ; Kodashima Shinya 1 ; Abe, Hiroyuki 3 ; Ushiku Tetsuo 3 ; Yamamichi Nobutake 1 ; Koike Kazuhiko 1 ; Fujishiro Mitsuhiro 1 

 The University of Tokyo Hospital, Department of Gastroenterology, Graduate School of Medicine, Tokyo, Japan (GRID:grid.412708.8) (ISNI:0000 0004 1764 7572) 
 Hokkaido University Hospital, Department of Gastroenterology, Sapporo, Japan (GRID:grid.412167.7) (ISNI:0000 0004 0378 6088) 
 The University of Tokyo Hospital, Department of Pathology, Tokyo, Japan (GRID:grid.412708.8) (ISNI:0000 0004 1764 7572) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2666718629
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.