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Abstract
Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo PD. It is associated with greater cognitive impairment and brain atrophy. However, the relation between structural brain characteristics and cognition remains poorly understood. We aimed to investigate subcortical and cortical atrophy in de novo PD with probable RBD (PD-pRBD) and to relate it with cognitive impairment. We analyzed volumetry, cortical thickness, and cognitive measures from 79 PD-pRBD patients, 126 PD without probable RBD patients (PD-non pRBD), and 69 controls from the Parkinson’s Progression Markers Initiative (PPMI). Regression models of cognition were tested using magnetic resonance imaging measures as predictors. We found lower left thalamus volume in PD-pRBD compared with PD-non pRBD. Compared with controls, PD-pRBD group showed atrophy in the bilateral putamen, left hippocampus, left amygdala, and thinning in the right superior temporal gyrus. Specific deep gray matter nuclei volumes were associated with impairment in global cognition, phonemic fluency, processing speed, and visuospatial function in PD-pRBD. In conclusion, cognitive impairment and gray matter atrophy are already present in de novo PD-pRBD. Thalamus, hippocampus, and putamen volumes were mainly associated with these cognitive deficits.
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1 University of Barcelona, Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775)
2 University of Barcelona, Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775); University of Toronto, Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Canada (GRID:grid.17063.33) (ISNI:0000 0001 2157 2938)
3 University of Barcelona, Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775); Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII), Barcelona, Spain (GRID:grid.430579.c) (ISNI:0000 0004 5930 4623)
4 Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775); Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII), Barcelona, Spain (GRID:grid.430579.c) (ISNI:0000 0004 5930 4623); University of Barcelona, Parkinson’s Disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institute of Neurosciences, Barcelona, Spain (GRID:grid.5841.8) (ISNI:0000 0004 1937 0247)
5 Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain (GRID:grid.10403.36) (ISNI:0000000091771775); Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII), Barcelona, Spain (GRID:grid.430579.c) (ISNI:0000 0004 5930 4623); Hospital Clínic de Barcelona, Multidisciplinary Sleep Disorders Unit, Neurology Service, Barcelona, Spain (GRID:grid.410458.c) (ISNI:0000 0000 9635 9413)