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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: To evaluate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in characterizing between malignant and benign renal lesions confirmed by histological examination. Methods: Overall, 110 patients, for a total of 118 renal masses previously identified at CT and MRI underwent CEUS. An expert radiologist evaluated morphological, qualitative and quantitative parameters. Acquired data were analyzed to assess the value of each parameter to differentiate between malignant and benign lesions. Results: Histological results of 118 renal masses showed 88 (75%) malignant lesions and 30 (25%) benign lesions. Among morphological features, inhomogeneous echogenicity was the best predictor of malignancy depicting a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 76%, 76%, 88% and 57%, respectively. Among qualitative parameters, the most reliable parameter was the presence of pseudo-capsule. Here, sensitivity, specificity, positive PPV and NPV were 85%, 86%, 94% and 71%, respectively. Among quantitative parameters, the most reliable parameters were peak intensity (PI) and the area under the (AUC) with sensitivity, specificity, PPV and NPV values of 94%, 92%, 96% and 87% and 99%, 92%, 97% and 97%, respectively. Finally, the most reliable parameters were combined to distinguish between benign and malignant lesions. The best combination obtained was restricted to CEUS parameters (PI and AUC). Here, sensitivity, specificity, PPV, NPV and accuracy rate were 93%, 100%, 100%, 83% and 93%, respectively. Conclusions: CEUS increases the US accuracy to discriminate between benign and malignant renal lesions.

Details

Title
Contrast-Enhanced Ultrasound (CEUS) in the Evaluation of Renal Masses with Histopathological Validation—Results from a Prospective Single-Center Study
Author
Tufano, Antonio 1 ; Drudi, Francesco Maria 2 ; Angelini, Flavia 2 ; Polito, Eleonora 2 ; Martino, Milvia 2 ; Granata, Antonio 3   VIAFID ORCID Logo  ; Di Pierro, Giovanni Battista 1   VIAFID ORCID Logo  ; Kutrolli, Eriselda 2 ; Sampalmieri, Matteo 1 ; Canale, Vittorio 1 ; Rocco Simone Flammia 1   VIAFID ORCID Logo  ; Fresilli, Daniele 2 ; Bertolotto, Michele 4   VIAFID ORCID Logo  ; Costantino Leonardo 1 ; Franco, Giorgio 1 ; Cantisani, Vito 2 

 Department of Urology, University La Sapienza, 00185 Roma, Italy; [email protected] (G.B.D.P.); [email protected] (M.S.); [email protected] (V.C.); [email protected] (R.S.F.); [email protected] (C.L.); [email protected] (G.F.) 
 Department of Radiology, Oncology and Pathology, University La Sapienza, 00185 Roma, Italy; [email protected] (F.M.D.); [email protected] (F.A.); [email protected] (E.P.); [email protected] (M.M.); [email protected] (E.K.); [email protected] (D.F.); [email protected] (V.C.) 
 Nephrology and Dialysis Unit, “Cannizzaro” Hospital, 95122 Catania, Italy; [email protected] 
 Department of Radiology, University of Trieste, 34127 Trieste, Italy; [email protected] 
First page
1209
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20754418
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2670132405
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.