Full text

Turn on search term navigation

© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Oxygen pulse (O2P) is a function of stroke volume and cellular oxygen extraction and O2P curve pattern (O2PCP) can provide continuous measurements of O2P. However, measurements of these two components are difficult during incremental maximum exercise. As cardiac function is evaluated using ejection fraction (EF) according to the guidelines and EF can be obtained using first-pass radionuclide ventriculography, the aim of this study was to investigate associations of O2P%predicted and O2PCP with EF in patients with heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF) and chronic obstructive pulmonary disease (COPD), and also in normal controls. This was a prospective observational cross-sectional study. Correlations of resting left ventricular EF, dynamic right and left ventricular EFs and outcomes with O2P% and O2PCP across the three participant groups were analyzed. A total of 237 male subjects were screened and 90 were enrolled (27 with HFrEF/HFmrEF, 30 with COPD and 33 normal controls). O2P% and the proportions of the three types of O2PCP were similar across the three groups. O2P% reflected dynamic right and left ventricular EFs in the control and HFrEF/HFmrEF groups, but did not reflect resting left ventricular EF in all participants. O2PCP did not reflect resting or dynamic ventricular EFs in any of the subjects. A decrease in O2PCP was significantly related to nonfatal cardiac events in the HFrEF/HFmrEF group (log rank test, p = 0.01), whereas O2P% and O2PCP did not predict severe acute exacerbations of COPD. The findings of this study may clarify the utility of O2P and O2PCP, and may contribute to the currently used interpretation algorithm and the strategy for managing patients, especially those with HFrEF/HFmrEF. (Trial registration number NCT05189301.)

Details

Title
The Impact of Oxygen Pulse and Its Curve Patterns on Male Patients with Heart Failure, Chronic Obstructive Pulmonary Disease, and Healthy Controls—Ejection Fractions, Related Factors and Outcomes
Author
Ming-Lung Chuang 1 ; Chin-Feng, Tsai 2 ; Kwo-Chang Ueng 2 ; Jui-Hung Weng 3 ; Ming-Fong Tsai 4 ; Chien-Hsien Lo 5 ; Gang-Bin Chen 6 ; Sung-Kien Sia 2 ; Yao-Tsung Chuang 2 ; Wu, Tzu-Chin 6 ; Pan-Fu, Kao 3 ; Hsieh, Meng-Jer 7   VIAFID ORCID Logo 

 Division of Pulmonary Medicine and Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; [email protected] (G.-B.C.); [email protected] (T.-C.W.); School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; [email protected] (C.-F.T.); [email protected] (K.-C.U.); [email protected] (J.-H.W.); [email protected] (S.-K.S.); [email protected] (Y.-T.C.); [email protected] (P.-F.K.) 
 School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; [email protected] (C.-F.T.); [email protected] (K.-C.U.); [email protected] (J.-H.W.); [email protected] (S.-K.S.); [email protected] (Y.-T.C.); [email protected] (P.-F.K.); Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; [email protected] 
 School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan; [email protected] (C.-F.T.); [email protected] (K.-C.U.); [email protected] (J.-H.W.); [email protected] (S.-K.S.); [email protected] (Y.-T.C.); [email protected] (P.-F.K.); Department of Nuclear Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan 
 Department of Nuclear Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi 61301, Taiwan; [email protected] 
 Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; [email protected]; Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan 
 Division of Pulmonary Medicine and Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan; [email protected] (G.-B.C.); [email protected] (T.-C.W.) 
 Department of Respiratory Therapy, Chang Gung University, Taoyuan 33303, Taiwan; Department of Pulmonary and Critical Care Medicine, Chiayi Chang Gung Memorial Hospital, Chang Gung Medical Foundation, Chiayi 61301, Taiwan 
First page
703
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
20754426
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2670200604
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.