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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Animals exhibit a wide variety of genetically determined coat colors and pigmentation patterns that serve important roles in adaptation and communication. Although the genetics of the main coat colors in dogs have been studied extensively, there are types of coat pigmentation that have not been explained yet. Recently, an association between the variants in the ASIP gene Ventral (VP) and Hair Cycle (HCP) promoters with different coat colors in dogs has been established. Here, we used the new findings as a basis to investigate the genetics of the red sesame coat color in Shiba Inu dogs. Our study revealed that red sesame dogs carry a specific heterozygous ASIP promoter diplotype, VP2-HCP1/VP2-HCP3, where VP2-HCP1 is responsible for the red coat with a dark overlay, and VP2-HCP3 for a tan point-like pattern. This finding explains the inheritance of this coat color pattern and can be used by breeders to produce dogs with this rare phenotype. A comparison of sesame dogs (VP2-HCP1/VP2-HCP3) to a dog homozygous for the VP2-HCP1 promoter haplotype suggests that the incomplete dominance between the ASIP alleles may be involved in the sesame coat formation. These results are in good agreement with the new model explaining how different levels of ASIP gene expression affect the regulation of pigment synthesis in melanocytes.

Details

Title
ASIP Promoter Variants Predict the Sesame Coat Color in Shiba Inu Dogs
Author
Belyakin, Stepan N 1   VIAFID ORCID Logo  ; Maksimov, Daniil A 2 ; Pobedintseva, Maria A 2   VIAFID ORCID Logo  ; Laktionov, Petr P 3 ; Voronova, Dinara 4 

 Genomics Laboratory, Institute of Molecular and Cellular Biology, 630090 Novosibirsk, Russia; [email protected] (D.A.M.); [email protected] (M.A.P.); [email protected] (P.P.L.); VetGenomics Laboratory, 630090 Novosibirsk, Russia 
 Genomics Laboratory, Institute of Molecular and Cellular Biology, 630090 Novosibirsk, Russia; [email protected] (D.A.M.); [email protected] (M.A.P.); [email protected] (P.P.L.) 
 Genomics Laboratory, Institute of Molecular and Cellular Biology, 630090 Novosibirsk, Russia; [email protected] (D.A.M.); [email protected] (M.A.P.); [email protected] (P.P.L.); Laboratory of Epigenetics, Novosibirsk State University, 630090 Novosibirsk, Russia 
 Russian Nihonken Hozonkai (NIPPO) Club, 129626 Moscow, Russia; [email protected] 
First page
222
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
23067381
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2670428746
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.