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© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Hypertension is a serious condition that is spread worldwide and may lead to severe complications such as heart attack, stroke, hypertensive retinopathy, and renal failure. Although some genetic and environmental risk factors are known to play a role in the etiology of hypertension, like most of the other multi-factorial diseases, its etiology is yet to be fully elucidated. Our study aimed to investigate the effects of methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and A1298C (rs1801131), factor V Leiden (FVL) G1691A (rs6025), and prothrombin (PT) G20210A (rs1799963) genetic polymorphisms on the development risk of essential hypertension and level of blood pressure in hypertensive patients.

Results

The frequency of the homozygous polymorphic TT genotype for the MTHFR C677T polymorphism was significantly higher in male hypertensive patients than in the male control group (27% vs 6.3%, p = 0.028). The rate of the variant T allele for the MTHFR C677T polymorphism was also significantly higher in male hypertensive patients compared to male healthy controls (51.4% vs 21.9%, p = 0.0004). There was no difference among hypertensive patients and healthy controls regarding the frequencies of MTHFR A1298C, FVL G1691A and PT G20210A polymorphisms. In addition, we found no difference between genotype groups regarding systolic and diastolic blood pressure levels in hypertensive patients.

Conclusions

Homozygous polymorphic TT genotype and variant T allele for the MTHFR C677T polymorphism may be considered as a risk factor for the development of essential hypertension in the Turkish male population.

Details

Title
MTHFR C677T (rs1801133) genetic polymorphism is associated with development risk of essential hypertension in the Turkish population
Author
Er, Zafer Cengiz 1   VIAFID ORCID Logo  ; Muderrisoglu, Ahmet 2   VIAFID ORCID Logo  ; Ekim, Meral 3   VIAFID ORCID Logo  ; Ekim, Hasan 1   VIAFID ORCID Logo 

 Yozgat Bozok University, Department of Cardiovascular Surgery, Faculty of Medicine, Yozgat, Turkey (GRID:grid.411743.4) (ISNI:0000 0004 0369 8360) 
 Kırıkkale University, Department of Pharmacology, Faculty of Medicine, Kırıkkale, Turkey (GRID:grid.411047.7) (ISNI:0000 0004 0595 9528) 
 Yozgat Bozok University, Department of Emergency Aid and Disaster Management, Faculty of Health Sciences, Yozgat, Turkey (GRID:grid.411743.4) (ISNI:0000 0004 0369 8360) 
Pages
4
Publication year
2022
Publication date
Dec 2022
Publisher
Springer Nature B.V.
ISSN
11108630
e-ISSN
20902441
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2670525196
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.