Abstract

Background

Our case explored the spectrum of autoimmune and infectious neurological complications of Coronavirus Disease 2019. In addition, we also reviewed and discussed clinical features, neuroimaging, CSF findings, and outcomes in patients with COVID-19-associated Myelin Oligodendrocyte Glycoprotein Antibody Disorder (MOGAD) CNS inflammatory disorder.

Case presentation

Here we presented a case of post-Coronavirus Disease 2019 infection Myelin Oligodendrocyte Glycoprotein Antibody Disorder in a 41-year-old male who presented with gait instability, urinary retention, and confusion. Workup done in hospital showed transverse myelitis in cervical spine region and left optic neuritis. Laboratory findings showed Myelin Oligodendrocyte Glycoprotein-IgG antibodies were positive in serum (1:100), suggestive of post-COVID Myelin Oligodendrocyte Glycoprotein Antibody Disorder.

Conclusion

To our knowledge, this is the first comprehensive case report and the literature review that includes the clinical features, neuroimaging, CSF findings, and outcomes in COVID-19-associated Myelin Oligodendrocyte Glycoprotein Antibody Disorder.

Details

Title
Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis and myelitis in COVID-19: a case report and a review of the literature
Author
Colantonio, Mark A. 1 ; Nwafor, Divine C. 1 ; Jaiswal, Shruti 2 ; Shrestha, Ashish K. 3 ; Elkhooly, Mahmoud 4 ; Rollins, Steven 5 ; Wen, Sijin 5 ; Sriwastava, Shitiz 6   VIAFID ORCID Logo 

1  West Virginia University, School of Medicine, Morgantown, USA (GRID:grid.268154.c) (ISNI:0000 0001 2156 6140) 
2  West Virginia Clinical and Translational Science Institute, Morgantown, USA (GRID:grid.268154.c) (ISNI:0000 0001 2156 6140) 
3  Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal (GRID:grid.415089.1) (ISNI:0000 0004 0442 6252) 
4  Minia University, Department of Neuropsychiatry, Minia, Egypt (GRID:grid.411806.a) (ISNI:0000 0000 8999 4945) 
5  West Virginia University, Department of Biostatistics, Morgantown, USA (GRID:grid.268154.c) (ISNI:0000 0001 2156 6140) 
6  West Virginia University, School of Medicine, Morgantown, USA (GRID:grid.268154.c) (ISNI:0000 0001 2156 6140); West Virginia Clinical and Translational Science Institute, Morgantown, USA (GRID:grid.268154.c) (ISNI:0000 0001 2156 6140); West Virginia University, Department of Neurology, Rockefeller Neuroscience Institute, Morgantown, USA (GRID:grid.268154.c) (ISNI:0000 0001 2156 6140) 
Publication year
2022
Publication date
Dec 2022
Publisher
Springer Nature B.V.
ISSN
11101083
e-ISSN
16878329
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s41983-022-00496-4
ProQuest document ID
2671814328
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.