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© 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Down syndrome (DS) is the most common chromosomal survival aneuploidy. The increase in DS life expectancy further heightens the risk of dementia, principally early‐onset Alzheimer's disease (AD). AD risk in DS is higher, considering that this population may also develop metabolic diseases such as obesity, dyslipidemias, and diabetes mellitus. The extra genetic material that characterizes DS causes an imbalance in the genetic dosage, including over‐expression of AD's key pathophysiological molecules and the gene expression regulators, the microRNAs (miRNAs). Two miRNAs, chromosome 21‐encoded, miR‐155, and let‐7c, are associated with cognitive impairment and dementia in adults; but, expression dynamics and relationship with clinical variables during the DS's lifespan had remained hitherto unexplored.

Methods

The anthropometric, clinical, biochemical, and profile expression of circulating miR‐155 and let‐7c were analyzed in a population of 52 control and 50 DS subjects divided into the young group (Aged ≤20 years) and the adult group (Aged ≥21 years).

Results

The expression changes for miR‐155 were not significant; nevertheless, a negative correlation with HDL‐Cholesterol concentrations was observed. Notably, let‐7c was over‐expressed in DS from young and old ages.

Conclusion

Overall, our results suggest that let‐7c plays a role from the early stages of DS's cognitive impairment while overexpression of miR‐155 may be related to lipid metabolism changes. Further studies of both miRNAs will shed light on their potential as therapeutic targets to prevent or delay DS's cognitive impairment.

Details

Title
Profiling of circulating chromosome 21‐encoded microRNAs, miR‐155, and let‐7c, in down syndrome
Author
Jesús Manuel Pérez‐Villarreal 1 ; Katia Aviña‐Padilla 2 ; Evangelina Beltrán‐López 3 ; Alma Marlene Guadrón‐Llanos 4   VIAFID ORCID Logo  ; Esther López‐Bayghen 5 ; Javier Magaña‐Gómez 6 ; Marco Antonio Meraz‐Ríos 7 ; Alfredo Varela‐Echavarría 8 ; Carla Angulo‐Rojo 9   VIAFID ORCID Logo 

 Laboratorio de Neurociencias, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Mexico; Maestría en Ciencias Biomédicas, Facultad de Ciencias Químico‐Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Mexico; Laboratorio de Nutrición Molecular, Escuela de Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Mexico 
 Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico; Laboratorio de Bioinformática y de Redes Complejas, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV‐IRAPUATO), Mexico 
 Laboratorio Edificio Central, Facultad de Ciencias Químico‐Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Mexico 
 Laboratorio de Diabetes y comorbilidades, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Mexico 
 Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV‐IPN), México City, Mexico 
 Maestría en Ciencias Biomédicas, Facultad de Ciencias Químico‐Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Mexico; Laboratorio de Nutrición Molecular, Escuela de Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Mexico 
 Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV‐IPN), México City, Mexico 
 Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico 
 Laboratorio de Neurociencias, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Mexico; Centro de Investigación y Docencia en Ciencias de la Salud (CIDOCS), Universidad Autónoma de Sinaloa, Culiacán, Mexico 
Section
ORIGINAL ARTICLES
Publication year
2022
Publication date
Jun 2022
Publisher
John Wiley & Sons, Inc.
e-ISSN
23249269
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2674547115
Copyright
© 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.