Abstract

The effectiveness of the inactivated BBIBP-CorV vaccine against severe COVID-19 outcomes (hospitalization, critical care admission and death due to COVID-19) and its long-term effectiveness have not been well characterized among the general population. We conducted a retrospective cohort study using electronic health records of 3,147,869 adults, of which 1,099,886 vaccinated individuals were matched, in a 1:1 ratio to 1,099,886 unvaccinated persons. A Cox-proportional hazard model with time varying coefficients was used to assess the vaccine effectiveness adjusting for age, sex, comorbidity, ethnicity, and the calendar month of entry into the study. Our analysis showed that the effectiveness was 79.6% (95% CI, 77.7 to 81.3) against hospitalization, 86% (95% CI, 82.2 to 89.0) against critical care admission, and 84.1% (95% CI, 70.8 to 91.3) against death due to COVID-19. The effectiveness against these severe outcomes declined over time indicating the need for booster doses to increase protection against severe COVID-19 outcomes.

There is limited real-world evidence for the effectiveness of the BBIBP-CorV (Sinopharm) vaccine against severe COVID-19 disease. Here, the authors use data from Abu Dhabi and estimate effectiveness at 80% against hospitalization; 86% against critical care admission and 84% against death.

Details

Title
Effectiveness of BBIBP-CorV vaccine against severe outcomes of COVID-19 in Abu Dhabi, United Arab Emirates
Author
Al Kaabi, Nawal 1 ; Oulhaj, Abderrahim 2 ; Ganesan, Subhashini 3   VIAFID ORCID Logo  ; Al Hosani, Farida Ismail 4 ; Najim, Omer 5 ; Ibrahim, Halah 6   VIAFID ORCID Logo  ; Acuna, Juan 7 ; Alsuwaidi, Ahmed R. 8 ; Kamour, Ashraf M. 9 ; Alzaabi, Ashraf 8 ; Al Shehhi, Badreyya Ahmed 10 ; Al Safar, Habiba 11   VIAFID ORCID Logo  ; Hussein, Salah Eldin 9 ; Abdalla, Jehad Saleh 9 ; Al Mansoori, Dalal Saeed Naser 12 ; Al Hammadi, Ahmed Abdul Kareem 12 ; Amari, Mohammed A. 9 ; Al Romaithi, Ahmed Khamis 9 ; Weber, Stefan 13 ; Elavalli, Santosh 14 ; Eltantawy, Islam 15 ; Alghaithi, Noura Khamis 16 ; Al Azazi, Jumana Nafiz 17 ; Holt, Stephen Geoffrey 18 ; Mostafa, Mohamed 19 ; Halwani, Rabih 20   VIAFID ORCID Logo  ; Khalak, Hanif 21 ; Elamin, Wael 21   VIAFID ORCID Logo  ; Beiram, Rami 8 ; Zaher, Walid 22 

1  Sheikh Khalifa Medical City SEHA, Abu Dhabi, UAE (GRID:grid.415670.1) (ISNI:0000 0004 1773 3278); Khalifa University, College of Medicine and Health Sciences, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729) 
2  Khalifa University, College of Medicine and Health Sciences, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729); United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, UAE (GRID:grid.43519.3a) (ISNI:0000 0001 2193 6666); Khalifa University, Research and Data Intelligence Support Center, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729) 
3  G42 Healthcare, Masdar City, Abu Dhabi, UAE (GRID:grid.440568.b); IROS (Insights Research Organization & Solutions), Abu Dhabi, UAE (GRID:grid.440568.b) 
4  Abu Dhabi Public Health Center – ADPHC, Abu Dhabi, UAE (GRID:grid.440568.b) 
5  Department of Health (DOH), Abu Dhabi, UAE (GRID:grid.440568.b) 
6  Khalifa University, College of Medicine and Health Sciences, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729) 
7  Khalifa University, College of Medicine and Health Sciences, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729); Khalifa University, Research and Data Intelligence Support Center, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729) 
8  United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, UAE (GRID:grid.43519.3a) (ISNI:0000 0001 2193 6666) 
9  Sheikh Khalifa Medical City SEHA, Abu Dhabi, UAE (GRID:grid.415670.1) (ISNI:0000 0004 1773 3278) 
10  Abu Dhabi Public Health Center – ADPHC, Abu Dhabi, UAE (GRID:grid.43519.3a) 
11  Khalifa University of Science and Technology, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729); Khalifa University of Science and Technology, College of Engineering, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729); Ministry of Interior, Emirates Bio-Research Center, Abu Dhabi, UAE (GRID:grid.440568.b) 
12  Tawam hospital SEHA, Al Ain, UAE (GRID:grid.416924.c) (ISNI:0000 0004 1771 6937) 
13  Reference Laboratory for Infectious Diseases (RLID) and Union 71, Abu Dhabi, UAE (GRID:grid.415670.1) 
14  G42 Healthcare, Masdar City, Abu Dhabi, UAE (GRID:grid.415670.1) 
15  IROS (Insights Research Organization & Solutions), Abu Dhabi, UAE (GRID:grid.415670.1) 
16  Ambulatory Health Services- SEHA, Abu Dhabi, UAE (GRID:grid.415670.1) 
17  Abu Dhabi Health Services Company- SEHA, Abu Dhabi, UAE (GRID:grid.507374.2) (ISNI:0000 0004 1756 0733); Abu Dhabi Executive Office, Abu Dhabi, UAE (GRID:grid.507374.2) 
18  SEHA Kidney Care, SEHA, Abu Dhabi Health Services Company, Abu Dhabi, UAE (GRID:grid.507374.2) (ISNI:0000 0004 1756 0733) 
19  Clinical research organization, PDC -CRO, Dubai, UAE (GRID:grid.507374.2) 
20  University of Sharjah, College of Medicine, Sharjah, UAE (GRID:grid.412789.1) (ISNI:0000 0004 4686 5317) 
21  G42 Healthcare, Masdar City, Abu Dhabi, UAE (GRID:grid.412789.1) 
22  Khalifa University, College of Medicine and Health Sciences, Abu Dhabi, UAE (GRID:grid.440568.b) (ISNI:0000 0004 1762 9729); United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, UAE (GRID:grid.43519.3a) (ISNI:0000 0001 2193 6666); G42 Healthcare, Masdar City, Abu Dhabi, UAE (GRID:grid.43519.3a); IROS (Insights Research Organization & Solutions), Abu Dhabi, UAE (GRID:grid.43519.3a) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-022-30835-1
ProQuest document ID
2674579057
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.