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Abstract
Endoscopic submucosal dissection can remove large superficial gastrointestinal lesions in en bloc. A detailed pathological evaluation of the resected specimen is required to assess the risk of recurrence after treatment. However, the current method of sectioning specimens to a thickness of a few millimeters does not provide information between the sections that are lost during the preparation. In this study, we have produced three-dimensional images of the entire dissected lesion for nine samples by using micro-CT imaging system. Although it was difficult to diagnose histological type on micro-CT images, it successfully evaluates the extent of the lesion and its surgical margins. Micro-CT images can depict sites that cannot be observed by the conventional pathological diagnostic process, suggesting that it may be useful to use in a complementary manner.
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1 Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, Department of Pathology, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952); Jichi Medical University, Department of Medicine, Division of Gastroenterology, Shimotsuke, Japan (GRID:grid.410804.9) (ISNI:0000000123090000)
2 Memorial Sloan Kettering Cancer Center, Gastroenterology, Hepatology and Nutrition Service, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952)
3 Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, Department of Pathology, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952)
4 Memorial Sloan Kettering Cancer Center, MSKCC Josie Robertson Surgery Center, Department of Pathology, New York, USA (GRID:grid.51462.34) (ISNI:0000 0001 2171 9952); Shizuoka Cancer Center, Division of Endoscopy, Shizuoka, Japan (GRID:grid.415797.9) (ISNI:0000 0004 1774 9501)