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Abstract
Since the start of SARS-CoV-2 pandemic, children aged ≤ 12 years have always been defined as underrepresented in terms of SARS-CoV-2 infections’ frequency and severity. By correlating SARS-CoV-2 transmission dynamics with clinical and virological features in 612 SARS-CoV-2 positive patients aged ≤ 12 years, we demonstrated a sizeable circulation of different SARS-CoV-2 lineages over the four pandemic waves in paediatric population, sustained by local transmission chains. Age < 5 years, highest viral load, gamma and delta clades positively influence this local transmission. No correlations between COVID-19 manifestations and lineages or transmission chains are seen, except for a negative correlation between B.1.1.7 and hospitalization.
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Details
1 Bambino Gesù Children Hospital IRCCS, Multimodal Research Area, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809); University of Milan, Department of Oncology and Hemato-Oncology, Milan, Italy (GRID:grid.4708.b) (ISNI:0000 0004 1757 2822)
2 Bambino Gesù Children Hospital IRCCS, Multimodal Research Area, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809)
3 Bambino Gesù Children Hospital IRCCS, Multimodal Research Area, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809); Bambino Gesù Children Hospital IRCCS, Microbiology and Diagnostics of Immunology Unit, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809)
4 Bambino Gesù Children Hospital IRCCS, Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809)
5 Bambino Gesù Children’s Hospital, IRCCS, Academic Department of Pediatrics, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809)
6 Bambino Gesù Children Hospital IRCCS, Microbiology and Diagnostics of Immunology Unit, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809)