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Abstract
Musa acuminata (MA) is a popular fruit peels in the world. Non-food parts of the plant have been investigated for their antioxidant and anti-ulcerative colitis activity. Metabolomic approaches were found to be informative as a screening tool. It discovered different metabolites depending on statistical analysis. The antioxidant activity content was measured by colorimetric method. Seventy six investigated metabolites were observed. The identities of some of these markers were confirmed based on their MS2 fragmentation and NMR spectroscopy. These include: cinnamic acid and its dimer 2-hydroxy-4-(4-methoxyphenyl)-1H-phenalen-1-one beside; gallic acid and flavonoids; quercetin, quercetin-3-O-β-d-glucoside, luteolin-7-O-β-d-glucopyranoside. GC/MS analysis of MA peels essential oil led to identification of 37 compounds. The leaves, pseudostem and fruit peels extracts were tested for their safety and their anti-ulcerative colitis efficacy in rats. Rats were classified into: normal, positive, prednisolone reference group, MA extracts pretreated groups (250–500 mg/kg) for 2 weeks followed by induction of ulcerative colitis by per-rectal infusion of 8% acetic acid. Macroscopic and microscopic examinations were done. Inflammatory markers (ANCA, CRP and Ilβ6) were measured in sera. The butanol extracts showed good antioxidant and anti-inflammatory activities as they ameliorated macroscopic and microscopic signs of ulcerative colitis and lowered the inflammatory markers compared to untreated group. MA wastes can be a potential source of bioactive metabolites for industrial use and future employment as promising anti-ulcerative colitis food supplements.
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Details
1 National Research Centre, Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, Giza, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157)
2 National Research Centre, Pharmacology Department, Medicine and Clinical Studies Research Institute, Giza, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157)
3 National Research Centre, Medical Biochemistry Department, Medicine and Clinical Studies Research Institute, Cairo, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157); October University for Modern Sciences and Arts, Faculty of Biotechnology, Giza, Egypt (GRID:grid.442760.3) (ISNI:0000 0004 0377 4079)
4 Cairo University, Pathology Department, Faculty of Veterinary Medicine, Giza, Egypt (GRID:grid.7776.1) (ISNI:0000 0004 0639 9286)
5 National Research Centre, Department of Phytochemistry and Plant Systematics, Pharmaceutical and Drug Industries Research Institute, Cairo, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157)