Full text

Turn on search term navigation

© 2019. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: The 6-min walk test (6MWT) allows exercise tolerance to be assessed, and it has a significant prognostic value in COPD. The goal of this study was to analyse the determinants (obtained in routine practice) of a low 6-min walking distance (6MWD) and exercise-induced desaturation (EID) in COPD, including comorbidities.

Methods: Patients were recruited from the real-life French COPD cohort “Initiatives BPCO”. A low 6MWD was defined as <350 m. EID was defined by a minimum pulse oxygen saturation (SpO2)<90% and delta SpO2≥4% from baseline. Multivariate logistic regression analyses assessed the influence on 6MWD and EID of age, sex, obesity (body mass index, BMI >30 kg/m2,), low BMI (BMI <18.5 kg/m2,), modified Medical Research Council (mMRC) dyspnea scale, FEV1% pred, FVC % pred, hyperinflation and comorbidities including cardiovascular diseases.

Results: Among 440 patients with available 6MWT data, a 6MWD <350 m was found in 146 patients (33%), which was positively associated in multivariate analyses with age and mMRC and negatively with resting SpO2 and FVC % pred (rescaled r2,=0.34), whereas no comorbidity was associated with a low 6WMD. EID was found in 155 patients (35%). This was positively associated with hypertension and negatively with age, obesity, FEV1% pred and resting SpO2 (rescaled r2,=0.37).

Conclusion: 6MWD and EID exhibit different determinants in COPD with a minor impact of comorbidities limited to hypertension in EID and to obesity, which was unexpectedly associated with less EID. Other variables including age, routine resting lung function and SpO2 were weakly associated with 6MWD and EID. Altogether, these results suggest that 6MWT performance remains difficult to predict with routine clinical/functional parameters.

Details

Title
Predictors in routine practice of 6-min walking distance and oxygen desaturation in patients with COPD: impact of comorbidities
Author
Perez, T  VIAFID ORCID Logo  ; Deslée, G; Burgel PR  VIAFID ORCID Logo  ; Caillaud, D  VIAFID ORCID Logo  ; Le Rouzic O  VIAFID ORCID Logo  ; Zysman, M  VIAFID ORCID Logo  ; Escamilla, R; Jebrak, G; Chanez, P; Court-Fortune, I  VIAFID ORCID Logo  ; Brinchault-Rabin, G; Nesme-Meyer, P; Paillasseur, J L; Roche, N  VIAFID ORCID Logo 
Pages
1399-1410
Section
Original Research
Publication year
2019
Publication date
2019
Publisher
Dove Medical Press Ltd.
ISSN
11769106
e-ISSN
11782005
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2679747555
Copyright
© 2019. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.