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© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

By using operant models of oral self-administration in rats, the authors found that the loss of function of PAC1 receptor in the nucleus accumbens shell leads to increased alcohol drinking and increased motivation for alcohol, suggesting that the PACAP/PAC1 receptor system in this brain area may act as a “brake” on excessive alcohol drinking. Importantly, to date, there are limited data available that elucidate the use liability of entactogen stimulants in female subjects, and that may be related to the limited exposure to the drug. [...]the authors initially determined whether long access to intravenous self-administration of three entactogens leads to escalation of drug intake in female rats, as it does in males. [...]they investigated the neuroadaptations in synaptic transmission in the CeA by performing whole-cell patch-clamp electrophysiology to assess changes in CeA GABA transmission and its regulation by the dynorphin/κ-opioid receptor system in female MDMA- and pentylone-exposed rats. [...]Curley et al. provide an overview of recent studies regarding the molecular mechanisms related to the role of corticotropin releasing factor binding protein (CRFBP) in the progression of addiction and other psychiatric disorders, biological aging, and age-related neurodegenerative disease.

Details

Title
Editorial: The Role of Neuropeptides in Drug Addiction and Other Psychiatric Disorders
Author
Lutfy, Kabirullah; Hipolito, Lucia; Ferretti, Valentina; Vendruscolo, Leandro F; Kallupi, Marsida
Section
EDITORIAL article
Publication year
2022
Publication date
Jun 28, 2022
Publisher
Frontiers Research Foundation
e-ISSN
1662-5153
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2681629900
Copyright
© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.