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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Surface coatings of materials by polysaccharide polymers are an acknowledged strategy to modulate interfacial biocompatibility. Polysaccharides from various algal species represent an attractive source of structurally diverse compounds that have found application in the biomedical field. Furcellaran obtained from the red algae Furcellaria lumbricalis is a potential candidate for biomedical applications due to its gelation properties and mechanical strength. In the present study, immobilization of furcellaran onto polyethylene terephthalate surfaces by a multistep approach was studied. In this approach, N-allylmethylamine was grafted onto a functionalized polyethylene terephthalate (PET) surface via air plasma treatment. Furcellaran, as a bioactive agent, was anchored on such substrates. Surface characteristics were measured by means of contact angle measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Subsequently, samples were subjected to selected cell interaction assays, such as antibacterial activity, anticoagulant activity, fibroblasts and stem cell cytocompatibility, to investigate the Furcellaran potential in biomedical applications. Based on these results, furcellaran-coated PET films showed significantly improved embryonic stem cell (ESC) proliferation compared to the initial untreated material.

Details

Title
Furcellaran Surface Deposition and Its Potential in Biomedical Applications
Author
Štěpánková, Kateřina 1   VIAFID ORCID Logo  ; Ozaltin, Kadir 1   VIAFID ORCID Logo  ; Pelková, Jana 2 ; Pištěková, Hana 1 ; Karakurt, Ilkay 1   VIAFID ORCID Logo  ; Káčerová, Simona 1 ; Lehocky, Marian 3   VIAFID ORCID Logo  ; Humpolicek, Petr 3   VIAFID ORCID Logo  ; Vesel, Alenka 4 ; Mozetic, Miran 4   VIAFID ORCID Logo 

 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Trida Tomase Bati 5678, 76001 Zlin, Czech Republic; [email protected] (K.Š.); [email protected] (K.O.); [email protected] (H.P.); [email protected] (I.K.); [email protected] (S.K.); [email protected] (P.H.) 
 Department of Haematology, Tomas Bata Regional Hospital, Havlickovo Nabrezi 2916, 76001 Zlin, Czech Republic; [email protected]; Faculty of Humanities, Tomas Bata University in Zlín, Stefanikova 5670, 76001 Zlin, Czech Republic 
 Centre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Trida Tomase Bati 5678, 76001 Zlin, Czech Republic; [email protected] (K.Š.); [email protected] (K.O.); [email protected] (H.P.); [email protected] (I.K.); [email protected] (S.K.); [email protected] (P.H.); Faculty of Technology, Tomas Bata University in Zlín, Vavreckova 5669, 76001 Zlin, Czech Republic 
 Department of Surface Engineering, Jozef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia; [email protected] (A.V.); [email protected] (M.M.) 
First page
7439
Publication year
2022
Publication date
2022
Publisher
MDPI AG
ISSN
16616596
e-ISSN
14220067
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2686122992
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.