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Abstract
Children with orofacial clefting (OFC) present with a wide range of dental anomalies. Identifying these anomalies is vital to understand their etiology and to discern the complex phenotypic spectrum of OFC. Such anomalies are currently identified using intra-oral exams by dentists, a costly and time-consuming process. We claim that automating the process of anomaly detection using deep neural networks (DNNs) could increase efficiency and provide reliable anomaly detection while potentially increasing the speed of research discovery. This study characterizes the use of` DNNs to identify dental anomalies by training a DNN model using intraoral photographs from the largest international cohort to date of children with nonsyndromic OFC and controls (OFC1). In this project, the intraoral images were submitted to a Convolutional Neural Network model to perform multi-label multi-class classification of 10 dental anomalies. The network predicts whether an individual exhibits any of the 10 anomalies and can do so significantly faster than a human rater can. For all but three anomalies, F1 scores suggest that our model performs competitively at anomaly detection when compared to a dentist with 8 years of clinical experience. In addition, we use saliency maps to provide a post-hoc interpretation for our model’s predictions. This enables dentists to examine and verify our model’s predictions.
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Details
1 University of Iowa, Department of Management Sciences, Tippie College of Business, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
2 University of the Philippines, Department of Pediatrics, College of Medicine, Manila, Philippines (GRID:grid.11159.3d) (ISNI:0000 0000 9650 2179)
3 University of Texas Health Science Center at Houston, Department of Pediatrics, Houston, USA (GRID:grid.267308.8) (ISNI:0000 0000 9206 2401)
4 CEMIC-CONICET, ECLAMC at Center for Medical Education and Clinical Research, Buenos Aires, Argentina (GRID:grid.267308.8)
5 Federal University of Rio de Janeiro, ECLAMC at Department of Genetics, Institute of Biology, Rio de Janeiro, Brazil (GRID:grid.8536.8) (ISNI:0000 0001 2294 473X)
6 University of Puerto Rico, Dental and Craniofacial Genomics Core, School of Dental Medicine, San Juan, USA (GRID:grid.267033.3) (ISNI:0000 0004 0462 1680)
7 University of Iowa, Department of Oral Pathology, Radiology, and Medicine, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa, The Iowa Institute for Oral Health Research, College of Dentistry, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
8 Clinica Noel, Medellín, Colombia (GRID:grid.214572.7)
9 University of Iowa, Department of Health Management and Policy, College of Public Health, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
10 University of Pittsburgh, Center for Craniofacial and Dental Genetics, School of Dental Medicine, Pittsburgh, USA (GRID:grid.21925.3d) (ISNI:0000 0004 1936 9000)
11 University of Iowa, The Iowa Institute for Oral Health Research, College of Dentistry, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa, Department of Orthodontics, College of Dentistry, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)
12 University of Iowa, The Iowa Institute for Oral Health Research, College of Dentistry, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa, Department of Family Dentistry, College of Dentistry, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294)