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Copyright © 2022 Vanessa Marques Meccatti et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes “LED” on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.

Details

Title
Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
Author
Vanessa Marques Meccatti 1   VIAFID ORCID Logo  ; de Souza Moura, Larissa 1   VIAFID ORCID Logo  ; Juliana Guerra Pinto 2   VIAFID ORCID Logo  ; Ferreira-Strixino, Juliana 2   VIAFID ORCID Logo  ; Amjad Abu Hasna 3   VIAFID ORCID Logo  ; Lívia Mara Alves Figueiredo-Godoi 1   VIAFID ORCID Logo  ; Juliana Campos Junqueira 1   VIAFID ORCID Logo  ; Marcucci, Maria Cristina 1   VIAFID ORCID Logo  ; de Paula Ramos, Lucas 1   VIAFID ORCID Logo  ; Claudio Antonio Talge Carvalho 3 ; Cesar Rogério Pucci 4   VIAFID ORCID Logo  ; Luciane Dias de Oliveira 1 

 Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil 
 Photobiology Applied to Health (PHOTOBIOS)—University of Vale do Paraiba, Research and Development Institute. Av. Shishima Hifumi, 2911—São José dos Campos, São Paulo, Brazil 
 Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil 
 Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil 
Editor
Halim Issever
Publication year
2022
Publication date
2022
Publisher
John Wiley & Sons, Inc.
ISSN
16878728
e-ISSN
16878736
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2687532046
Copyright
Copyright © 2022 Vanessa Marques Meccatti et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/