Abstract

Some COVID-19 patients experience dyspnea without objective impairment of pulmonary or cardiac function. This study determined diaphragm function and its central voluntary activation as a potential correlate with exertional dyspnea after COVID-19 acute respiratory distress syndrome (ARDS) in ten patients and matched controls. One year post discharge, both pulmonary function tests and echocardiography were normal. However, six patients with persisting dyspnea on exertion showed impaired volitional diaphragm function and control based on ultrasound, magnetic stimulation and balloon catheter-based recordings. Diaphragm dysfunction with impaired voluntary activation can be present 1 year after severe COVID-19 ARDS and may relate to exertional dyspnea.

This prospective case–control study was registered under the trial registration number NCT04854863 April, 22 2021

Details

Title
Diaphragm dysfunction as a potential determinant of dyspnea on exertion in patients 1 year after COVID-19-related ARDS
Author
Spiesshoefer, Jens; Friedrich, Janina; Regmi, Binaya; Geppert, Jonathan; Benedikt Jörn; Kersten, Alexander; Giannoni, Alberto; Boentert, Matthias; Marx, Gernot; Marx, Nikolaus; Daher, Ayham; Dreher, Michael
Pages
1-6
Section
Correspondence
Publication year
2022
Publication date
2022
Publisher
BioMed Central
ISSN
1465993X
e-ISSN
14659921
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s12931-022-02100-y
ProQuest document ID
2691329458
Copyright
© 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.