Abstract

INTRODUCTION: Insulin resistance (IR) is a key and early pathogenetic mechanism of cardiometabolic diseases with huge potential if detected early and mitigated, for lowering the burden of the disease. Available data are conflicting to what extent adult thyroid dysfunction is associated with IR. Therefore, we aimed to investigate the association and to identify which thyroid parameters are predictors of IR.
MATERIAL AND METHODS: After undergoing basic anthropometric and biochemical studies including thyroid hormones, oral glucose tolerance test (OGTT), and insulin, 1425 middle-aged individuals were divided into three groups according to thyroid parameters: overt hypothyroidism (OH), subclinical hypothyroidism (SH), and euthyroidism (EU).
RESULTS: The homeostasis model assessment of IR (HOMA-IR), fasting insulin, and two-hour glucose levels of OGTT showed a steady, yet insignificant, increase from EU through SH to OH. The strongest noted correlations were those of insulin levels with free triiodothyronine/free thyroxine (FT3/FT4) ratio (r = 0.206, p < 0.001) and FT3 (r = 0.205, p < 0.001). Also in the case of HOMA-IR, the only statistically significant correlations were observed for FT3 (r = 0.181, p < 0.001) and the FT3/FT4 ratio (r = 0.165, p < 0.001). Among other thyroid hormones, linear logistic regression proved the FT3/FT4 ratio as the only significant predictor of HOMA-IR (linear coefficient = 5.26, p = 0.027) and insulin levels (linear coefficient = 18.01, p = 0.023), respectively. Thyroid-stimulating hormone was not associated with IR in either correlation or regression analysis.
CONCLUSIONS: The FT3/FT4 ratio should be more emphasised in the diagnosis and treatment of thyroid disorders. Patients could benefit from a pharmacological reduction of the FT3/FT4 ratio, potentially leading to a decrease in insulin resistance, and thus a corresponding decrease in the risk of the cardiometabolic diseases.

Details

Title
Free triiodothyronine/free thyroxine (FT3/FT4) ratio is strongly associated with insulin resistance in euthyroid and hypothyroid adults: a cross-sectional study
Author
Štěpánek, Ladislav 1   VIAFID ORCID Logo  ; Horáková, Dagmar 2   VIAFID ORCID Logo  ; Štěpánek, Lubomír 3 ; Janout, Vladimír 2   VIAFID ORCID Logo  ; Janoutová, Jana 4   VIAFID ORCID Logo  ; Bouchalová, Kateřina 5   VIAFID ORCID Logo  ; Martiník, Karel 6 

1  Department of Public Health, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic. [email protected] 
2  Department of Public Health, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic 
3  Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Prague, Czech Republic 
4  Department of Healthcare Management, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czech Republic 
5  Department of Pediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic 
6  Ambulance Prof. MUDr. Karla Martiníka DrSc. s.r.o, Hradec Králové, Czech Republic 
First page
8
End page
13
Publication year
2021
Publication date
2021
Publisher
Wydawnictwo Via Medica
ISSN
0423104X
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.5603/EP.a2020.0066
ProQuest document ID
2692731245
Copyright
© 2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.