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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Most COVID-19 fatalities have occurred among older adults; however, evidence regarding the determinants of SARS-CoV-2 infection in this population is limited. Telephone interviews were conducted in November 2020 with a representative sample of 4400 Italians aged ≥65 years from the Lombardy region. We determined the prevalence of a history of SARS-CoV-2 infection. Through unconditional multiple logistic regression models, we estimated the odds ratios (ORs) of infection and the corresponding 95% confidence intervals (CIs). We further evaluated whether infection was related to a reduction in mental wellbeing. Of the participants, 4.9% reported a previous infection. No significant relationship between sex and infection was observed. Prior infection was less frequently reported in subjects aged ≥70 (OR = 0.55; 95% CI: 0.41–0.74) compared to 65–69 years, with no trend after 70 years of age. Those with at least one chronic condition reported a lower infection rate compared to healthy subjects (OR = 0.68; 95% CI: 0.49–0.93). Participants who lived alone more frequently reported infection than those who cohabited (OR = 2.33; 95% CI: 1.29–4.20). Prior infection was related to increased depressive symptoms (OR = 1.57; 95% CI: 1.17–2.10). This representative study of people aged ≥65 years suggests that in Italy, the oldest subjects and chronic patients less frequently exposed themselves to SARS-CoV-2 infection.

Details

Title
Determinants of SARS-CoV-2 Infection in the Older Adult Population: Data from the LOST in Lombardia Study
Author
Mosconi, Giansanto 1 ; Stival, Chiara 2 ; Lugo, Alessandra 2   VIAFID ORCID Logo  ; Signorelli, Carlo 3   VIAFID ORCID Logo  ; Amerio, Andrea 4   VIAFID ORCID Logo  ; Luca Cavalieri d’Oro 5 ; Iacoviello, Licia 6   VIAFID ORCID Logo  ; Stuckler, David 7 ; Zucchi, Alberto 8 ; Odone, Anna 9   VIAFID ORCID Logo  ; Gallus, Silvano 2   VIAFID ORCID Logo  ; Cosby, S Louise

 Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy; [email protected] 
 Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy; [email protected] (C.S.); [email protected] (A.L.); [email protected] (S.G.) 
 Department School of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy; [email protected] 
 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy; [email protected]; IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy 
 Agenzia di Tutela della Salute della Brianza, 20900 Monza, Italy; [email protected] 
 Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy; [email protected]; Department of Epidemiology and Prevention, IRCCS Neuromed, 86077 Pozzilli, Italy 
 Department of Social Sciences and Politics, Bocconi University, 20136 Milan, Italy; [email protected] 
 Agenzia di Tutela della Salute di Bergamo, 24121 Bergamo, Italy; [email protected] 
 Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy; [email protected]; Department School of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy; [email protected] 
First page
989
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
2076393X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2694093010
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.