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Abstract
Forced oscillation technique (FOT) provides unique information on respiratory system mechanical properties complementing pulmonary function testing. However, a lack of evidence guiding acquisition/reporting of parameters has slowed clinical FOT adoption. Current European Respiratory Society (ERS) standards recommend 3–5 trials per session comprising three trials with a coefficient of variation (CoV) ≤ 10% for low-frequency resistance. We present an analysis of different combinations of trial selection methods and session validity thresholding variables (low- and mid-frequency resistance and reactance [R5, R19, X5], low-frequency reactance area [AX] and tidal volume) comparing proportion of subjects achieving valid data across two test sessions (7 ± 3 days apart) and within and between session measurement variabilities. 126 (98%) subjects achieved valid data across both sessions (2666 trials). With R5 or R19 as criteria and selection of any three trials from ≥ 4 attempts, ≥ 75% of subjects achieved validity. Furthermore, with R5 or R19 criteria and selection of any trials from ≥ 5 attempts, CoVs for resistance outcomes were reduced within session while variabilities of FOT outcomes between sessions remained consistent. Within session differences in measurement variabilities were not clinically meaningful. Our analyses support current ERS reporting recommendations for healthy adults. Future work should apply this analytic approach to patient populations.
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1 VA New Jersey Health Care System, Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, East Orange, USA (GRID:grid.422069.b) (ISNI:0000 0004 0420 0456)
2 VA New Jersey Health Care System, Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, East Orange, USA (GRID:grid.422069.b) (ISNI:0000 0004 0420 0456); Rutgers Biomedical and Health Sciences, Rutgers New Jersey Medical School, Newark, USA (GRID:grid.430387.b) (ISNI:0000 0004 1936 8796)
3 Rowan University, School of Osteopathic Medicine, Stratford, USA (GRID:grid.262671.6) (ISNI:0000 0000 8828 4546)
4 VA New Jersey Health Care System, Airborne Hazards and Burn Pits Center of Excellence, War Related Illness and Injury Study Center, East Orange, USA (GRID:grid.422069.b) (ISNI:0000 0004 0420 0456); Rutgers New Jersey Medical School, Department of Pharmacology, Physiology and Neuroscience, Newark, USA (GRID:grid.430387.b) (ISNI:0000 0004 1936 8796); Rutgers New Jersey Medical School, Department of Physical Medicine and Rehabilitation, Newark, USA (GRID:grid.430387.b) (ISNI:0000 0004 1936 8796)