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ABSTRACT:

The Mission of this research is to formulate and enhance the release of Diclofenac sodium utilising Tamarind Kernel Gum (TKG) as natural polymer. The study investigated the potential of TKG by comparing with Hydroxy Propyl Methyl Cellulose (HPMC) and Sodium Carboxy Methyl Cellulose (Na CMC). Nine formulations were designed, three of which incorporated TKG, HPMC and Sodium CMC. Wet Granulation Technique was employed for the formulation of Diclofenac sodium matrix tablets and evaluation tests were performed to check the performance of tablets. The study sought to examine the effect of various matrix formers on the release retardant property The formulations, comprised of tamarind kernel gum, had a longer duration release profile, as demonstrated by invitro studies and kinetic analysis In conclusion, the use of natural polymer in diclofenac sodium tablet formulation offers the promise of sustained release medications.

KEYWORDS: Diclofenac Sodium, Tamarind Kernel Gum, Hydroxy Propyl Methyl Cellulose, Sodium CMC, Wet Granulation, Sustained Release.

INTRODUCTION:

Ninety percent of the intake of medicine presumably occurs by the oral route. Oral dosage formulations are the most often used drug delivery route1. This is evidenced by the fact that in comparison to other oral dosage forms, Tablets are the manufacturer's favoured form because of its greater stability, virtually tamper-resistant, and fairly low cost of production, packing and distribution2. The design of controlled release formulations is of great interest in pharmaceutical research especially for NSAID like Diclofenac sodium.

Diclofenac sodium is well known for its properties that provide relief from pain and reduce inflammation, on the other hand due to its short half-life, frequent dosage is required, that could trigger gastro intestinal adverse effects3. controlled release formulation development may eliminate these challenges by ensuring a constant medication release at a zero order in nature by perpetually releasing a quantity proportional to the amount the body eliminates over time4. Matrix type of approach is suitable for the formulation that has a homogenous dispersion of the API inside hydrophilic or hydrophobic polymers that prolong the release rate5. Polymers have been widely used for medication delivery due to their unique features that cannot be mirrored by material alternatives. Natural Polymers are intriguing because of their affordability, versatility to various chemical alterations and numerous dervitizable groups6. Natural Gums feature as one of...

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