Abstract

Host-virus associations have co-evolved under ecological and evolutionary selection pressures that shape cross-species transmission and spillover to humans. Observed virus-host associations provide relevant context for newly discovered wildlife viruses to assess knowledge gaps in host-range and estimate pathways for potential human infection. Using models to predict virus-host networks, we predicted the likelihood of humans as hosts for 513 newly discovered viruses detected by large-scale wildlife surveillance at high-risk animal-human interfaces in Africa, Asia, and Latin America. Predictions indicated that novel coronaviruses are likely to infect a greater number of host species than viruses from other families. Our models further characterize novel viruses through prioritization scores and directly inform surveillance targets to identify host ranges for newly discovered viruses.

Potential host range and spillover risk for novel viruses can be predicted using a network informed by known virus-host associations.

Details

Title
Predicting the potential for zoonotic transmission and host associations for novel viruses
Author
Pandit, Pranav S. 1   VIAFID ORCID Logo  ; Anthony, Simon J. 2 ; Goldstein, Tracey 1   VIAFID ORCID Logo  ; Olival, Kevin J. 3   VIAFID ORCID Logo  ; Doyle, Megan M. 1 ; Gardner, Nicole R. 1   VIAFID ORCID Logo  ; Bird, Brian 1 ; Smith, Woutrina 1 ; Wolking, David 1 ; Gilardi, Kirsten 1 ; Monagin, Corina 1 ; Kelly, Terra 1 ; Uhart, Marcela M. 1   VIAFID ORCID Logo  ; Epstein, Jonathan H. 3   VIAFID ORCID Logo  ; Machalaba, Catherine 3 ; Rostal, Melinda K. 3   VIAFID ORCID Logo  ; Dawson, Patrick 3 ; Hagan, Emily 3 ; Sullivan, Ava 3 ; Li, Hongying 3 ; Chmura, Aleksei A. 3 ; Latinne, Alice 3 ; Lange, Christian 4 ; O’Rourke, Tammie 4 ; Olson, Sarah 5   VIAFID ORCID Logo  ; Keatts, Lucy 1   VIAFID ORCID Logo  ; Mendoza, A. Patricia 6   VIAFID ORCID Logo  ; Perez, Alberto 7 ; de Paula, Cátia Dejuste 5 ; Zimmerman, Dawn 8   VIAFID ORCID Logo  ; Valitutto, Marc 8 ; LeBreton, Matthew 9 ; McIver, David 10 ; Islam, Ariful 3   VIAFID ORCID Logo  ; Duong, Veasna 11   VIAFID ORCID Logo  ; Mouiche, Moctar 9 ; Shi, Zhengli 12   VIAFID ORCID Logo  ; Mulembakani, Prime 13 ; Kumakamba, Charles 14 ; Ali, Mohamed 15 ; Kebede, Nigatu 16 ; Tamoufe, Ubald 17 ; Bel-Nono, Samuel 18 ; Camara, Alpha 19 ; Pamungkas, Joko 20 ; Coulibaly, Kalpy J. 21 ; Abu-Basha, Ehab 22   VIAFID ORCID Logo  ; Kamau, Joseph 23 ; Silithammavong, Soubanh 24 ; Desmond, James 3 ; Hughes, Tom 25   VIAFID ORCID Logo  ; Shiilegdamba, Enkhtuvshin 26 ; Aung, Ohnmar 8 ; Karmacharya, Dibesh 27 ; Nziza, Julius 28 ; Ndiaye, Daouda 29 ; Gbakima, Aiah 30 ; Sajali, Zikankuba 31 ; Wacharapluesadee, Supaporn 32 ; Robles, Erika Alandia 33 ; Ssebide, Benard 34 ; Suzán, Gerardo 35 ; Aguirre, Luis F. 36   VIAFID ORCID Logo  ; Solorio, Monica R. 37 ; Dhole, Tapan N. 38 ; Nga, Nguyen T. T. 39 ; Hitchens, Peta L. 40   VIAFID ORCID Logo  ; Joly, Damien O. 41 ; Saylors, Karen 42 ; Fine, Amanda 5 ; Murray, Suzan 9 ; Karesh, William B. 3 ; Daszak, Peter 3   VIAFID ORCID Logo  ; Mazet, Jonna A. K. 1 ; Johnson, Christine K. 1   VIAFID ORCID Logo 

1  University of California, Davis, One Health Institute, School of Veterinary Medicine, Davis, USA (GRID:grid.27860.3b) (ISNI:0000 0004 1936 9684) 
2  Columbia University, Center for Infection and Immunity, New York, USA (GRID:grid.21729.3f) (ISNI:0000000419368729) 
3  EcoHealth Alliance, New York, USA (GRID:grid.420826.a) (ISNI:0000 0004 0409 4702) 
4  Labyrinth Global Health, Inc., St Petersburg, USA (GRID:grid.420826.a) 
5  Wildlife Conservation Society, Health Program, Bronx, USA (GRID:grid.269823.4) (ISNI:0000 0001 2164 6888) 
6  Wildlife Conservation Society, Health Program, Bronx, USA (GRID:grid.269823.4) (ISNI:0000 0001 2164 6888); Wildlife Conservation Society (WCS), Peru Program, Lima, Peru (GRID:grid.516986.5) 
7  Wildlife Conservation Society (WCS), Peru Program, Lima, Peru (GRID:grid.516986.5) 
8  Global Health Program, Smithsonian’s National Zoological Park and Conservation Biology Institute, Washington, USA (GRID:grid.467700.2) (ISNI:0000 0001 2182 2028) 
9  Mosaic/Global Viral Cameroon, Yaoundé, Cameroon (GRID:grid.452492.c) 
10  Metabiota Inc, Nanaimo, Canada (GRID:grid.452492.c) 
11  Institut Pasteur du Cambodge, Phnom Penh, Cambodia (GRID:grid.418537.c) (ISNI:0000 0004 7535 978X) 
12  Chinese Academy of Sciences, Wuhan Institute of Virology, Wuhan, China (GRID:grid.9227.e) (ISNI:0000000119573309) 
13  University of Kinshasa, Kinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo (GRID:grid.9783.5) (ISNI:0000 0000 9927 0991) 
14  Metabiota Inc., Kinshasa, Democratic Republic of the Congo (GRID:grid.9783.5) 
15  Egypt National Research Centre, Dokki, Egypt (GRID:grid.419725.c) (ISNI:0000 0001 2151 8157) 
16  Addis Ababa University, Aklilu Lemma Institute of Pathobiology, Addis Ababa, Ethiopia (GRID:grid.7123.7) (ISNI:0000 0001 1250 5688) 
17  Metabiota Cameroon Ltd, Yaoundé, Yaoundé, Cameroon (GRID:grid.452492.c) 
18  Military Veterinarian (Rtd.), Accra, Ghana (GRID:grid.452492.c) 
19  Centre de Recherche en Virologie (VRV) Projet Fievres Hemoraquiques en Guinée, Nongo/Contéya-Commune de Ratoma, Guinea (GRID:grid.452492.c) 
20  Bogor Agricultural University, Primate Research Center, Bogor, Indonesia (GRID:grid.440754.6) (ISNI:0000 0001 0698 0773); Bogor Agricultural University, Faculty of Veterinary Medicine, Bogor, Indonesia (GRID:grid.440754.6) (ISNI:0000 0001 0698 0773) 
21  Institut Pasteur de Côte d’Ivoire, Department Environment and Health, Abidjan 01, Ivory Coast (GRID:grid.418523.9) (ISNI:0000 0004 0475 3667) 
22  Jordan University of Science and Technology, Department of Basic Medical Veterinary Sciences, College of Veterinary Medicine, Ar-Ramtha, Jordan (GRID:grid.37553.37) (ISNI:0000 0001 0097 5797) 
23  Institute of Primate Research, Molecular Biology Laboratory, Nairobi, Kenya (GRID:grid.418948.8) (ISNI:0000 0004 0566 5415); University of Nairobi, Department of Biochemistry, Nairobi, Kenya (GRID:grid.10604.33) (ISNI:0000 0001 2019 0495) 
24  Metabiota Inc, Nanaimo, Canada (GRID:grid.10604.33) 
25  EcoHealth Alliance, New York, USA (GRID:grid.420826.a) (ISNI:0000 0004 0409 4702); Conservation Medicine, Sungai Buloh, Malaysia (GRID:grid.420826.a) 
26  Wildlife Conservation Society (WCS), Mongolia Program, Ulaanbaatar, Mongolia (GRID:grid.516924.d) 
27  Center for Molecular Dynamics Nepal (CMDN), Kathmandu, Nepal (GRID:grid.428196.0) 
28  Mountain Gorilla Veterinary Project, Regional Headquarters, Musanze, Rwanda (GRID:grid.428196.0) 
29  Université Cheikh Anta Diop, Dakar, Sénégal (GRID:grid.8191.1) (ISNI:0000 0001 2186 9619) 
30  Metabiota, Inc. Sierra Leone, Freetown, Sierra Leone (GRID:grid.8191.1) 
31  Sokoine University of Agriculture, Department of Veterinary Medicine and Public Health, College of Veterinary Medicine and Biomedical Sciences, Morogoro, Tanzania (GRID:grid.11887.37) (ISNI:0000 0000 9428 8105) 
32  King Chulalongkorn Memorial Hospital, Thai Red Cross Emerging Infectious Diseases Clinical Center, Bangkok, Thailand (GRID:grid.411628.8) (ISNI:0000 0000 9758 8584) 
33  Wildlife Conservation Society (WCS), Bolivia Program, La Paz, Bolivia (GRID:grid.516956.8) 
34  Mountain Gorilla Veterinary Project, Regional Headquarters, Musanze, Rwanda (GRID:grid.516956.8) 
35  Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia, México City, Mexico (GRID:grid.9486.3) (ISNI:0000 0001 2159 0001) 
36  Universidad Mayor de San Simón, Centro de Biodiversidad y Genética, Cochabamba, Bolivia (GRID:grid.10491.3d) (ISNI:0000 0001 2176 4059) 
37  Instituto de Medicina Veterinária (IMV) Universidade Federal do Pará (UFPA), Laboratório de Epidemiologia e Geoprocessamento (EpiGeo), Castanhal, Brazil (GRID:grid.10491.3d) 
38  Sanjay Gandhi Post Graduate Institute of Medical Sciences, Department of Microbiology, Lucknow, India (GRID:grid.263138.d) (ISNI:0000 0000 9346 7267) 
39  Wildlife Conservation Society (WCS), Vietnam Program, Hanoi, Vietnam (GRID:grid.263138.d) 
40  University of Melbourne, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, Werribee, Australia (GRID:grid.1008.9) (ISNI:0000 0001 2179 088X) 
41  Nyati Health Consulting, Nanaimo, Canada (GRID:grid.1008.9) 
42  Labyrinth Global Health, Inc., St Petersburg, USA (GRID:grid.1008.9) 
Pages
844
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
23993642
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s42003-022-03797-9
ProQuest document ID
2704130529
Copyright
© The Author(s) 2022. corrected publication 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.