Abstract

We aimed to evaluate the radiographic and clinical outcomes after gamma knife radiosurgery (GKRS) for trigeminal schwannomas (TSs). A total of 87 patients who underwent GKRS for TSs between 1990 and 2020 were enrolled. The mean tumor volume was 4.3 cm3. The median prescribed dose for the margins of the tumor was 13 Gy. The median follow-up duration was 64.3 months (range 12.0–311.5 months). The overall local tumor control rate was 90%, and the symptom response rate was 93%. The response rate for each symptom was 88% for facial pain, 97% for facial sensory change, and 86% for cranial nerve deficits. Nineteen (22%) patients showed transient swelling, which had regressed at the time of the last follow-up. Cystic tumors were associated with transient swelling (p = 0.04). A tumor volume of < 2.7 cm3 was associated with local tumor control in univariable analysis. Transient swelling was associated with symptom control failure in both univariable and multivariable analyses (p = 0.04, odds ratio 14.538). GKRS is an effective treatment for TSs, both for local control and symptom control.

Details

Title
Thirty-year clinical experience in gamma knife radiosurgery for trigeminal schwannomas
Author
Shin, Dong-Won 1 ; Ju, Chunseng 2 ; Lee, Hyun Seok 3 ; Yoo, Hee Jun 4 ; Song, Sang Woo 5 ; Cho, Young Hyun 5 ; Hong, Chang-Ki 5 ; Hong, Seok Ho 5 ; Lee, Do Heui 5 ; Kim, Jeong Hoon 5 ; Kim, Young-Hoon 5 

 University of Ulsan College of Medicine, Department of Neurological Surgery, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667); Gachon University College of Medicine, Department of Neurosurgery, Gil Medical Center, Incheon, Republic of Korea (GRID:grid.256155.0) (ISNI:0000 0004 0647 2973) 
 Suwon Ever Plastic Surgery Clinic, Department of Plastic Surgery, Suwon, Republic of Korea (GRID:grid.256155.0) 
 University of Ulsan College of Medicine, Department of Neurological Surgery, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667); Konkuk University Hospital, Department of Neurosurgery, Seoul, Republic of Korea (GRID:grid.411120.7) (ISNI:0000 0004 0371 843X) 
 University of Ulsan College of Medicine, Department of Neurological Surgery, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667); Chung-Ang University Gwangmyeong Hospital, Department of Neurosurgery, Gwangmyeong, Republic of Korea (GRID:grid.254224.7) (ISNI:0000 0001 0789 9563) 
 University of Ulsan College of Medicine, Department of Neurological Surgery, Asan Medical Center, Seoul, Republic of Korea (GRID:grid.267370.7) (ISNI:0000 0004 0533 4667) 
Publication year
2022
Publication date
2022
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2705582095
Copyright
© The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.