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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Oral papilloma lesions may appear as a result of HPV infection, or not, and only special molecular methods could differentiate them. Low-risk and high-risk HPV types could induce oral HPV papillomatosis with different natural evolution, clearance and persistence mechanisms. The pathogenic mechanisms are based on the crosstalk between the oral epithelial and immune cells and this very efficient virus. HPV acts as a direct inducer in the process of transforming a benign lesion into a malignant one, the cancerization process being also debated in this paper. According to the degree of malignity, three types of papillomatous lesions can be described in the oral cavity: benign lesions, potential malign disorders and malignant lesions. The precise molecular diagnostic is important to identify the presence of various virus types and also the virus products responsible for its oncogenicity. An accurate diagnostic of oral papilloma can be established through a good knowledge of etiological and epidemiological factors, clinical examination and laboratory tests. This review intends to update the pathogenic mechanisms driving the macroscopic and histological features of oral papillomatosis having HPV infection as the main etiological factor, focusing on its interreference in the local immunity. In the absence of an accurate molecular diagnostic and knowledge of local immunological conditions, the therapeutic strategy could be difficult to decide.

Details

Title
Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity—An Update
Author
Andrei, Elena Cristina 1 ; Baniță, Ileana Monica 1 ; Munteanu, Maria Cristina 2 ; Cristina Jana Busuioc 3 ; Mateescu, Garofița Olivia 3   VIAFID ORCID Logo  ; Mălin, Ramona Denise 4 ; Cătălina, Gabriela Pisoschi 5 

 Department of Histology, Faculty of Dentistry, University of Medicine and Pharmacy, 2-4 Petru Rareș Street, 200349 Craiova, Romania 
 Department of Oro-Maxillofacial Surgery, Faculty of Dentistry, University of Medicine and Pharmacy, 200349 Craiova, Romania 
 Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy, 200349 Craiova, Romania 
 Department of Otorhinolaryngology, University of Medicine and Pharmacy, 200349 Craiova, Romania 
 Department of Pharmaceutical Biochemistry, University of Medicine and Pharmacy, 200349 Craiova, Romania 
First page
1103
Publication year
2022
Publication date
2022
Publisher
MDPI AG
ISSN
1010660X
e-ISSN
16489144
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2706261298
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.