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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Iron oxide magnetic nanoparticles (MNPs) have been widely studied due to their versatility for diagnosis, tracking (magnetic resonance imaging (MRI)) and therapeutic (magnetic hyperthermia and drug delivery) applications. In this work, iron oxide MNPs with different single-core (8–40 nm) and multi-core (140–200 nm) structures were synthesized and functionalized by organic and inorganic coating materials, highlighting their ability as magnetic nanotools to boost cell biotechnological procedures. Single core Fe3O4@PDA, Fe3O4@SiO2-FITC-SiO2 and Fe3O4@SiO2-RITC-SiO2 MNPs were functionalized with fluorescent components with emission at different wavelengths, 424 nm (polydopamine), 515 (fluorescein) and 583 nm (rhodamine), and their ability as transfection and imaging agents was explored with HeLa cells. Moreover, different multi-core iron oxide MNPs (Fe3O4@CS, Fe3O4@SiO2 and Fe3O4@Citrate) coated with organic (citrate and chitosan, CS) and inorganic (silica, SiO2) shells were tested as efficient nanoheaters for magnetic hyperthermia applications for mild thermal heating procedures as an alternative to simple structures based on single-core MNPs. This work highlights the multiple abilities offered by the synergy of the use of external magnetic fields applied on MNPs and their application in different biomedical approaches.

Details

Title
Fluorescent Single-Core and Multi-Core Nanoprobes as Cell Trackers and Magnetic Nanoheaters
Author
Pelayo García Acevedo  VIAFID ORCID Logo  ; González Gómez, Manuel A  VIAFID ORCID Logo  ; Prieto, Ángela Arnosa  VIAFID ORCID Logo  ; Lisandra De Castro Alves  VIAFID ORCID Logo  ; Román Seco Gudiña  VIAFID ORCID Logo  ; Piñeiro, Yolanda  VIAFID ORCID Logo  ; Rivas, José  VIAFID ORCID Logo 
First page
83
Publication year
2022
Publication date
2022
Publisher
MDPI AG
e-ISSN
23127481
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2706272396
Copyright
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.